COGNITIVE BEHAVIORAL TREATMENT OF MEMORY PROBLEMS

记忆问题的认知行为治疗

• 批准号: 6310199
• 负责人: ROBERT J FERGUSON
• 金额: $ 7.95万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6310199
• 关键词: antineoplastics; attention; behavioral /social science research tag; breast neoplasms; cancer rehabilitation mental health service; cognitive behavior therapy; drug adverse effect; female; functional ability; human subject; human therapy evaluation; long term survivor; memory disorders; neuropsychological tests; patient oriented research; psychological aspect of cancer; quality of life; women's health

DESCRIPTION: (Applicant's Description) Cognitive deficits associated with cancer treatment can have a dramatic effect on patients' quality of life and have been recognized as a problem by the President's Cancer Panel (1999) and the National Coalition for Cancer Survivorship for those living with cancer (Ferrell Hassey & Dow, 1997). Increasing evidence suggests that standard dose, systemic chemotherapy can produce memory and concentration deficits in adult 5-year cancer survivors (Ahles, 1999). While more research on the cognitive effects of chemotherapy is needed, mounting evidence suggests strongly that development of interventions to improve cognitive functioning following chemotherapy is important. The present application proposes pilot testing a brief cognitive-behavioral treatment program (4 visits with 3 phone contacts) designed to assist breast cancer survivors in compensating for cognitive impairment associated with systemic chemotherapy. The principal long-term objective of this work is to examine the treatment program's feasibility to be carried out in clinical oncology settings at this pilot-phase of treatment development and examine its preliminary effectiveness in a small sample of cancer survivors. Results will aid planning and carry-through of a randomized controlled trial of efficacy in future investigation. Specific aims of the present project are: 1. To evaluate the feasibility of a brief cognitive-behavioral treatment program designed specifically for rehabilitation of cognitive deficits resulting from systemic chemotherapy. Breast cancer survivors will be the target population. 2. Pilot-test the effectiveness of the brief cognitive-behavioral treatment as a first-phase of treatment development (one-group, repeated measures design). 3. Quantify the proportion of treatment participants who achieve clinically significant improvement using statistical methods to determine clinically significant outcomes in behavioral research (Jacobson, Roberts, Berns, & McGlinchey, 1999). Clinically significant change will be defined as exceeding the reliable change index (RCI) in pre- to post-test scoring on self-report measures of cognitive functioning and quality of life measures. 4. Evaluate participant satisfaction with treatment. Thirty-three breast cancer survivors (5 years after disease remission) with attention and memory deficits will enroll in the pilot treatment. A single-group, 3 (time: pre-treatment, post-treatment, 2-month follow-up) X 1 (treatment group) repeated-measures, multivariate analysis of variance (MANOVA) design will be used to evaluate effects of treatment on three dependent measures: 1) standardized self-report measure of cognitive function; 2) a global neuropsychological test performance score; and 3) a self-report measure of survivor quality of life. Participant satisfaction and adherence to behavioral and cognitive homework tasks will also be assessed by quantifying these variables with descriptive statistics. Implications for future study are discussed.

描述：（申请人的描述） 与癌症治疗相关的认知缺陷可能会产生巨大的影响 影响患者的生活质量并被认为是一个问题 总统癌症小组 (1999) 和全国癌症联盟 癌症患者的生存率（Ferrell Hassey & Dow，1997）。 越来越多的证据表明，标准剂量的全身化疗可以 导致成年 5 年癌症幸存者记忆力和注意力缺陷 （阿勒斯，1999）。虽然更多关于化疗对认知影响的研究正在 需要的是，越来越多的证据强烈表明，干预措施的制定 改善化疗后的认知功能很重要。这 本申请提出了试点测试简短的认知行为 旨在帮助乳房的治疗计划（4 次就诊，3 次电话联系） 癌症幸存者补偿与相关的认知障碍 全身化疗。这项工作的主要长期目标是 检验治疗方案在临床上实施的可行性 治疗开发试验阶段的肿瘤学环境并检查其 在一小部分癌症幸存者中取得了初步效果。结果将 援助计划和实施随机对照疗效试验 未来的调查。本项目的具体目标是： 1. 评估短期认知行为治疗的可行性 专为认知缺陷康复而设计的计划 全身化疗所致。乳腺癌幸存者将是 目标人群。 2. 试点测试简短认知行为治疗的有效性 治疗开发的第一阶段（一组、重复措施设计）。 3. 量化达到临床效果的治疗参与者的比例 使用统计方法确定临床显着改善 行为研究的重大成果（雅各布森、罗伯茨、伯恩斯和 麦格林奇，1999）。临床上显着的变化将被定义为超过 自我报告测试前后评分的可靠变化指数（RCI） 认知功能测量和生活质量测量。 4. 评估参与者对治疗的满意度。 33 名乳腺癌幸存者（疾病缓解 5 年后） 注意力和记忆力缺陷将纳入试点治疗。一个 单组，3（时间：治疗前、治疗后、2个月随访）X 1 （治疗组）重复测量、多变量方差分析 （多元方差分析）设计将用于评估治疗对三种疾病的影响 依赖性测量：1）标准化的认知功能自我报告测量； 2) 整体神经心理学测试表现评分； 3）自我报告 衡量幸存者生活质量的指标。参与者的满意度和遵守情况 行为和认知作业任务也将通过量化来评估 这些变量具有描述性统计。对未来研究的影响是 讨论过。