CLINICAL EVALUATION OF THE VESTIBULO-OCULASR REFLEX

前庭眼反射的临床评估

• 批准号: 3083574
• 负责人: Timothy C Hain
• 金额: $ 7.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083574
• 关键词: body movement; ear disorder diagnosis; electrooculography; eye movements; head movements; human subject; labyrinth disorder; magnetic field; neurophysiology; nystagmus; stimulus /response; vertigo; vestibular apparatus; vestibuloocular reflex; vision disorders

The long term objective of our research is to better understand the mechanisms underlying both normal and abnormal vestibulo-ocular function. The aim of the present proposal is to develop new ways of testing and analyzing the vestibulo-ocular reflex (VOR). The research strategy is to make quantitative measurements of vestibulo-ocular function in humans using paradigms suggested by the results of both recent neurophysiological studies as well as mathematical analyses of VOR function. In particular, we will choose rotational vestibular and optokinetic stimuli that exceed the capabilities of or circumvent the compensatory mechanisms which normally make vestibular diagnosis so difficult. We will begin by applying the new methodology to the detection of unilateral peripheral vestibular disease (UPVD)--first in patients with complete loss, then those with partial loss--with the ultimate plan to extend our results to patients with central vestibular disorders. We plan to 1) use brief, high-velocity head-on-body movements to expose UPVD, 2) determine (with the magnetic field search coil technique) if inappropriately directed slow phase eye movements during high-velocity vertical or horizontal head rotations are a reliable index to UPVD, 3) develop a new test to measure vertical semicircular canal function by using their contribution to the horizontal (eye in head) VOR, 4) use the initial slow phase velocity profile (plateau effect), in response to a constant velocity head rotation, to detect UPVD and 5) examine the usefulness of optokinetic afternystagmus (OKAN) in assessment of UPVD. Our results will provide new information useful in the assessment of the large number of patients with nystagmus, visual blurring and oscillopsia, and vertigo and dizziness.

我们研究的长期目标是更好地了解 正常和异常的前庭功能的机制。 本提案的目的是开发新的测试方式和 分析前庭 - 眼反射（VOR）。 研究策略是 使用使用的定量测量用于人类的前庭 - 眼功能 两种近期神经生理学的结果提出的范例 VOR功能的研究以及数学分析。 尤其， 我们将选择超过的旋转前庭和光动力学刺激 补偿机制的能力或规避 通常使前庭诊断如此困难。 我们将从申请开始 检测单侧外围前庭的新方法 疾病（UPVD） - 首先是完全损失的患者，然后是 部分损失 - 最终计划将我们的结果扩展到患者 中央前庭疾病。 我们计划1）使用简短的高速度 面向身体运动以暴露UPVD，2）确定（使用磁性 现场搜索线圈技术）如果不恰当地定向慢相眼 高速垂直或水平头部旋转期间的运动是 可靠的upvd索引，3）开发一个新的测试以测量垂直测试 半圆形管功能通过其对水平的贡献 （头在头上）VOR，4）使用初始慢相速度曲线（高原 效果），响应恒定速度头旋转，以检测UPVD 5）检查光动量Afternystagmus（Okan）在 评估UPVD。 我们的结果将为您提供有用的新信息 评估大量眼球震颤患者，视觉模糊 和oscillopsia，以及眩晕和头晕。