HEMISPHERIC SPECIALIZATION OF HIGHER FUNCTIONS IN HUMANS

人类高级功能的半球特化

• 批准号: 3075593
• 负责人: ERAN ZAIDEL
• 金额: $ 8.58万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3075593
• 关键词: alcoholic beverage consumption; audiometry; behavior; binaural hearing; biomedical equipment development; caffeine; cerebral dominance; chronic brain damage; cognition; computer program /software; corpus callosums; drug adverse effect; eye movements; histology; human subject; language development; learning; magnetic resonance imaging; neural information processing; neurobiology; nicotine; postmortem; split brain; tachistoscope; visual perception

This is a request for an ADAHMA RSDA focusing on hemispheric specialization and interaction at the interface of language and cognition. A convergent research program is outlined which studies neurological patients and normal subjects and combines behavioral, anatomical and physiological methods. Technological developments include a powerful computer-based laboratory for laterality research and a eye-tracker with scotoma simulator for hemispheric occular scanning without attachments to the eye. Theoretical work will continue on behavioral models of laterality effects and conditions for parallel independent information processing in the two hemispheres. One set of experiments will study independent lexical access and organization, syntactic and pragmatic competence and associated cognitive abilities in each of the two hemispheres. A second set of experiments will analyze individual differences in regional patterns of callosal connectivity using behavioral, anatomical and physiological measures, in relation to cognitive profile, handedness and gender. Biological and environmental conditions that change hemispheric function and callosal connectivity will be investigated. A third set of experiments investigates issues of monitoring and control in interhemispheric relations, including learning, metacognition and error correction. Results promise better understanding and possible control of cognitive pathology due to abnormal cerebral activation or faulty interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by understanding how language is organized in the brain and how independent, parallel cortical processing modules interact. Plans for professional growth include (1) Collaborative research with other psychologists, linguists, and neuroscientists, (2) intensive study of neuroanatomy, neurophysiology and statistical analysis, and (3) tutorial visits to other labs to study techniques of event-related potentials, magnetic resonance imaging, clinical neurology, and cognitive psychology.

这是Adahma RSDA的要求，重点是半球 语言和认知界面的专业化和互动。 概述了一项收敛研究计划，研究神经系统 患者和正常受试者，结合了行为，解剖和 生理方法。 技术发展包括一个强大的基于计算机的实验室 用于横向研究和带有Scotoma模拟器的眼线笔 半球固定扫描，无眼附着。 理论 横向效应的行为模型将继续工作 两者中并行独立信息处理的条件 半球。 一组实验将研究独立的词汇访问和 组织，句法和务实能力以及相关的认知能力 两个半球的能力。 第二组实验将分析个人差异 使用行为，解剖学 和生理措施，与认知特征有关 和性别。 改变的生物和环境条件 将研究半球功能和callosal连接性。 第三组实验调查了监视和控制问题 在半球间关系中，包括学习，元认知和错误 更正。 结果有望更好地理解和可能控制认知 由于脑激活异常或半球间的病理 沟通。 数据将有助于理论认知 神经科学通过了解语言在大脑中的组织方式和 独立的平行皮层处理模块如何相互作用。 专业增长计划包括（1）与 其他心理学家，语言学家和神经科学家，（2）密集研究 神经解剖学，神经生理学和统计分析以及（3） 教程访问其他实验室以研究事件相关的技术 电势，磁共振成像，临床神经病学和认知 心理学。