SYNAPTIC TRANSMISSION IN THE CENTRAL NERVOUS SYSTEM

中枢神经系统中的突触传递

• 批准号: 3076134
• 负责人: ROSS J BALDESSARINI
• 金额: $ 5.94万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3076134
• 关键词: adenylate cyclase; adrenergic agents; aging; antiadrenergic agents; behavior test; central nervous system; corpus striatum; cow; developmental neurobiology; dopamine receptor; experimental brain lesion; high performance liquid chromatography; laboratory mouse; laboratory rat; neurochemistry; neurotransmitter metabolism; pharmacokinetics; phenylethylamines; psychopharmacology; psychotropic drugs; tranquilizer

This is a proposed continuation of an NIMH Research Scientist Award to provide salary support to continue projects that have already received separate grant support that deal with studies pertinent to synaptic transmission in the mammalian brain, with an emphasis on experiments aimed at increasing understanding of the pharmacology of antipsychotic agents and other psychotropic agents that interact with dopamine receptor sites in forebrain. The projects include studies of basic properties of sites that may represent dopamine receptors, especially those represented by high-affinity labeling with dopamine agonists; the evalution of complex dopamine analogs as probes of the chemical characteristics of dopamine receptor surfaces; the development and evaluation of novel dopamine analogs with agonist and regionally selective antagonist properties that may lead to clinically useful, novel psychotropic agents; the assessment of dopamine receptor properties as a function of developing and aging; and exploration of pharmacologic properties of available neuroleptic-antipsychotic agents as functions of development and age, of the circadian cycle, and of time following treatment, with behavioral and biochemical as well as some pharmacokinetic correlates in laboratory rodents and human subjects.

这是 NIMH 研究科学家奖的提议延续 提供薪资支持以继续已经收到的项目 处理与突触相关的研究的单独拨款支持 哺乳动物大脑中的传播，重点是旨在进行实验 加深对抗精神病药物药理学的了解 其他与多巴胺受体位点相互作用的精神药物 前脑。 这些项目包括对场地基本属性的研究 可以代表多巴胺受体，特别是由以下代表的那些 多巴胺激动剂高亲和力标记；复杂的评估 多巴胺类似物作为多巴胺化学特性的探针 受体表面；新型多巴胺类似物的开发和评价 具有激动剂和区域选择性拮抗剂特性，可能导致 临床上有用的新型精神药物；多巴胺的评估 受体特性作为发育和衰老的函数；和探索 现有精神安定药-抗精神病药的药理学特性 作为发育和年龄、昼夜节律周期和时间的函数 治疗后，进行行为和生化以及一些 实验室啮齿动物和人类受试者的药代动力学相关。