SYNAPTIC TRANSMISSION IN THE CENTRAL NERVOUS SYSTEM

中枢神经系统中的突触传递

• 批准号: 3076133
• 负责人: ROSS J BALDESSARINI
• 金额: $ 6.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3076133
• 关键词: adenylate cyclase; adrenergic agents; aging; antiadrenergic agents; behavior test; central nervous system; corpus striatum; cow; developmental neurobiology; dopamine receptor; experimental brain lesion; high performance liquid chromatography; laboratory mouse; laboratory rat; neurochemistry; neurotransmitter metabolism; pharmacokinetics; phenylethylamines; psychopharmacology; psychotropic drugs; tranquilizer

This is a proposed continuation of an NIMH Research Scientist Award to provide salary support to continue projects that have already received separate grant support that deal with studies pertinent to synaptic transmission in the mammalian brain, with an emphasis on experiments aimed at increasing understanding of the pharmacology of antipsychotic agents and other psychotropic agents that interact with dopamine receptor sites in forebrain. The projects include studies of basic properties of sites that may represent dopamine receptors, especially those represented by high-affinity labeling with dopamine agonists; the evalution of complex dopamine analogs as probes of the chemical characteristics of dopamine receptor surfaces; the development and evaluation of novel dopamine analogs with agonist and regionally selective antagonist properties that may lead to clinically useful, novel psychotropic agents; the assessment of dopamine receptor properties as a function of developing and aging; and exploration of pharmacologic properties of available neuroleptic-antipsychotic agents as functions of development and age, of the circadian cycle, and of time following treatment, with behavioral and biochemical as well as some pharmacokinetic correlates in laboratory rodents and human subjects.

这是NIMH研究科学家奖的拟议延续 提供工资支持以继续已收到的项目 与与突触有关的研究的单独赠款支持 哺乳动物大脑的传播，重点是针对实验 越来越了解抗精神病药的药理学和 与多巴胺受体位点相互作用的其他精神药物 前脑。 这些项目包括对网站的基本属性的研究 可能代表多巴胺受体，尤其是由 高亲和力标记多巴胺激动剂；复杂的评估 多巴胺类似物作为多巴胺化学特征的探针 受体表面；新型多巴胺类似物的发展和评估 具有可能导致的激动剂和区域选择性拮抗剂特性 临床上有用的新型精神药物；多巴胺的评估 受体特性是发展和衰老的函数；和探索 可用的神经肌肉抗精神剂的药理特性 作为发展和年龄的功能，昼夜节律的功能以及时间 治疗后，具有行为和生化以及一些 药代动力学在实验室啮齿动物和人类受试者中相关。