CONTROL OF OVARIAN FUNCTION IN THE PRIMATE

灵长类动物卵巢功能的控制

• 批准号: 3073107
• 负责人: Anthony J Zeleznik
• 金额: $ 5.53万
• 依托单位: MAGEE-WOMEN'S HOSPITAL OF UPMC
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-05-01 至 1989-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3073107
• 关键词: corpus luteum; estradiol; experimental brain lesion; follicle stimulating hormone; graafian follicles; hormone regulation /control mechanism; hypothalamus; luteinizing hormone; menstrual cycle; menstrual cycle disorder; ovulation; pituitary gonadal axis; progesterone; prolactin; radioimmunoassay; reproductive system circulation

The goals of research described in this application are twofold: to elucidate the mechanisms by which a single ovulatory follicle matures each cycle and to identify the physiological mechanisms by which the primate corpus luteum is regulated during the rhesus monkey menstrual cycle. Experiments presented herein will investigate whether the selected follicle inhibits the maturation of other follicles by suppressing gonadotropin secretion, and if the selected follicle is spared from this inhibition by its acquisition of a rich vasculature which allows it to preferentially receive gonadotropins. In addition, this research will define the dependency of the primate corpus luteum on pituitary gonadotropins during the early, mid, and late luteal phase of the menstrual cycle, identify the nature by which the corpus luteum perceives and responds to pituitary gonadotropins, and elucidates the site of action of estradiol in promoting luteal regression. In addition to providing definitive information regarding the physiological regulation of the primate ovary in vivo, the results obtained from these experiments may further our understanding of pathophysiological disturbances of the human menstrual cycle such as impaired follicle growth, the short luteal phase, and the inadequate luteal phase. Lastly, it is becoming increasingly apparent that pulsatile GnRH treatment will be used extensively in the treatment of certain types of amenorrhea in humans. Studies described in this application will provide important information regarding the maintenance of the corpus luteum in GnRH driven menstrual cycles, and in doing so, may directly guide clinical endocrinologists in the effective treatment of infertility.

本应用程序中描述的研究目标是双重的： 阐明单个排卵卵泡每次成熟的机制 循环并确定灵长类动物的生理机制 在恒河猴的月经周期中，曲目是在调节的。 本文提出的实验将研究选定的卵泡是否 通过抑制促性腺激素来抑制其他卵泡的成熟 分泌，如果选定的卵泡免于从这种抑制中 它对丰富的脉管系统的收购使其优先 接受促性腺激素。 此外，这项研究将定义 灵长类动物体质的依赖性对垂体性促性腺激素的依赖性 月经周期的早期，中和晚期阶段，确定 Luteum Copcus感知并回应垂体的自然 促性腺激素，并阐明雌二醇在促进中的作用部位 黄体回归。 除了提供有关生理学的明确信息 体内灵长类动物卵巢的调节，从中获得的结果 实验可能会进一步了解我们对病理生理学的理解 人类月经周期的干扰，例如卵泡生长受损， 短的黄体期和不足的黄体期。 最后，是 越来越明显地使用脉动GNRH治疗 广泛地治疗了人类某些类型的闭经。 本应用程序中描述的研究将提供重要信息 关于在GNRH驱动的月经 周期，这样做的，可以直接指导临床内分泌学家 不育的有效治疗。