CONTROL OF OVARIAN FUNCTION IN THE PRIMATE

灵长类动物卵巢功能的控制

• 批准号: 3073109
• 负责人: Anthony J Zeleznik
• 金额: $ 5.37万
• 依托单位: MAGEE-WOMEN'S HOSPITAL OF UPMC
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-05-01 至 1989-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3073109
• 关键词: Macaca mulatta; corpus luteum; estradiol; experimental brain lesion; follicle stimulating hormone; graafian follicles; hormone regulation /control mechanism; hypothalamus; luteinizing hormone; menstrual cycle; menstrual cycle disorder; ovulation; pituitary gonadal axis; progesterone; prolactin; radioimmunoassay; reproductive system circulation

The goals of research described in this application are twofold: to elucidate the mechanisms by which a single ovulatory follicle matures each cycle and to identify the physiological mechanisms by which the primate corpus luteum is regulated during the rhesus monkey menstrual cycle. Experiments presented herein will investigate whether the selected follicle inhibits the maturation of other follicles by suppressing gonadotropin secretion, and if the selected follicle is spared from this inhibition by its acquisition of a rich vasculature which allows it to preferentially receive gonadotropins. In addition, this research will define the dependency of the primate corpus luteum on pituitary gonadotropins during the early, mid, and late luteal phase of the menstrual cycle, identify the nature by which the corpus luteum perceives and responds to pituitary gonadotropins, and elucidates the site of action of estradiol in promoting luteal regression. In addition to providing definitive information regarding the physiological regulation of the primate ovary in vivo, the results obtained from these experiments may further our understanding of pathophysiological disturbances of the human menstrual cycle such as impaired follicle growth, the short luteal phase, and the inadequate luteal phase. Lastly, it is becoming increasingly apparent that pulsatile GnRH treatment will be used extensively in the treatment of certain types of amenorrhea in humans. Studies described in this application will provide important information regarding the maintenance of the corpus luteum in GnRH driven menstrual cycles, and in doing so, may directly guide clinical endocrinologists in the effective treatment of infertility.

本申请中描述的研究目标有两个： 阐明单个排卵卵泡成熟的机制 周期并确定灵长类动物的生理机制 黄体在恒河猴月经周期中受到调节。 本文提出的实验将调查所选卵泡是否 通过抑制促性腺激素抑制其他卵泡的成熟 分泌，并且如果选定的卵泡免受这种抑制 它获得了丰富的脉管系统，使其能够优先 接受促性腺激素。 此外，这项研究将定义 灵长类动物黄体对垂体促性腺激素的依赖性 月经周期的黄体早期、中期和晚期，确定 黄体感知和响应垂体的性质 促性腺激素，并阐明雌二醇促进促性腺激素的作用位点 黄体退化。 除了提供有关生理学的明确信息外 灵长类动物卵巢的体内调节，从这些获得的结果 实验可以进一步加深我们对病理生理学的理解 人类月经周期紊乱，例如卵泡生长受损， 黄体期短，黄体期不足。 最后，就是 越来越明显的是，将使用脉冲式 GnRH 治疗 广泛用于治疗人类某些类型的闭经。 本申请中描述的研究将提供重要信息 关于 GnRH 驱动的月经中黄体的维持 周期，这样做可以直接指导临床内分泌学家 有效治疗不孕症。