BEHAVIORAL BIOLOGY OF THE FETUS

胎儿的行为生物学

• 批准号: 3073358
• 负责人: WILLIAM P SMOTHERMAN
• 金额: $ 5.36万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3073358
• 关键词: animal developmental psychology; avoidance behavior; behavior test; body movement; embryo /fetus; laboratory rat; psychological reinforcement; taste; videotape /videodisc

Concern for the healthy development of the fetus continues to spawn considerable interest in prenatal behavior, yet relatively little is known about how a fetus behaves and responds to changes within its uterine environment. In spite of technological advances, methodological problems and ethical considerations have limited the study of the human fetus to indirect monitoring and postnatal inference. Therefore, direct observation and experimentation is possible only with nonhuman subjects. Recent technical developments now enable precise manipulation of the intrauterine environment of the rat fetus and observation of fetal behavior in utero. With the pregnant female rat surgically prepared by reversible spinal anesthesia and her uterus externalized into a warm saline bath, the intrauterine environment can be manipulated by intra-amniotic injection, chemosensory stimulation delivered by intraoral infusion, and behavior of the fetus directly observed through the uterine wall, through the amniotic membrane, or within an unrestrained fluid medium. These procedural tools now permit study of the developing mammalian fetus in its environment. This Research Career Development Award application outlines a general program of research to investigate the behavioral biology of the rat fetus. The principal objective of the proposed program is threefold: (a) to describe the normal behavioral development of the unmanipulated rat fetus in utero; (b) to characterize the behavior of the fetus in aversive and appetitive learning situations and to explore the role of fetal learning in subsequent behavioral development; and (c) to investigate the interplay between prenatal behavior and the development of behavioral and morphological anomalies.

关注胎儿健康发展的关注 对产前行为的极大兴趣，但鲜为人知 关于胎儿的行为和对子宫内变化的反应 环境。 尽管有技术进步，方法论问题 道德的考虑因素将人胎儿的研究限制为 间接监测和产后推断。 因此，直接观察 只有非人类受试者才有可能进行实验。 最近的 技术发展现在可以精确操纵宫内 大鼠胎儿的环境和子宫内胎儿行为的观察。 通过可逆脊柱手术制备的怀孕雌性大鼠 麻醉和她的子宫外在地进入温暖的盐水浴中， 宫内环境可以通过注射室内注射来操纵 通过术内输注提供的化学感应刺激和 胎儿通过子宫壁直接通过羊膜观察到 膜，或在不受约束的流体培养基中。 这些程序工具 现在，允许在其环境中研究发育中的哺乳动物胎儿。 该研究职业发展奖的应用程序概述了一般 研究大鼠行为生物学的研究计划 胎儿。 拟议计划的主要目标是三重：（a） 描述未经操纵大鼠的正常行为发展 子宫里的胎儿； （b）表征胎儿在厌恶中的行为 和食欲的学习情况并探索胎儿的作用 在随后的行为发展中学习； （c）调查 产前行为与行为的发展之间的相互作用和 形态异常。