BIOBEHAVIORAL STUDIES OF NARCOTICS ABUSE IN HUMANS

人类麻醉品滥用的生物行为研究

• 批准号: 3075370
• 负责人: JACK H MENDELSON
• 金额: $ 9.32万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-12-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3075370
• 关键词: Macaca mulatta; alcoholism /alcohol abuse; behavior test; cocaine; drug abuse chemotherapy; drug interactions; estradiol; female; female reproductive system disorder; follicle stimulating hormone; human subject; hyperprolactinemia; luteinizing hormone; magnetic resonance imaging; marijuana abuse; menstrual cycle disorder; neuroendocrine system; nuclear magnetic resonance spectroscopy; operant conditionings; opiate alkaloid; pituitary adrenal axis; pituitary gonadal axis; postmenopause; premenstrual syndrome; psychopharmacology; radioimmunoassay; reinforcer; self medication; substance abuse related disorder; tobacco abuse

The research proposed in this competing renewal application for an ADAMHA Research Scientist Award is based upon grants currently funded by NIDA and NIAAA which focus upon studies of polydrug abuse in women and female rhesus monkey. The experimental analysis of polydrug use patterns of marihuana, alcohol and tobacco will be carried out under controlled research ward conditions with operant behavioral procedures. The consequences of chronic cocaine abuse will be examined in patients and in a primate model of drug abuse where polydrug abuse cannot influence data obtained. The NIDA Clinical Research Center studies will also evaluate drug interactions and the role of premenstrual dysphoria on drug self-administration by women. Assessments of the efficacy and safety for adjunctive pharmacotherapies for cocaine, opiate and polydrug abuse will be evaluated in both patients and in female rhesus monkey. The NIAAA supported research grant program will examine alcohol effects on reproductive hormones in women as well as ethanol-induced alterations in neuroendocrine function which may modulate the reinforcing properties of alcohol. Effects of acute alcohol intoxication on pituitary, adrenal and gonadal hormones will be examined utilizing provocative tests of hypothalamic, pituitary, ovarian and adrenal function. Provocative tests will also be employed to determine mechanisms of alcohol-induced disruption of normal menstrual function in women of childbearing age and alcohol- induced alterations in endocrine function in post-menopausal women. Multidisciplinary approaches will be utilized in both the NIDA and NIAAA supported research Scientists from a variety of disciplines, including psychiatry, psychology, internal medicine, endocrinology, neurology, pharmacology, nursing and the social sciences, will participate in these investigations. The overall objectives of the proposed research are to clarify the behavioral and biologic determinants and consequences of substances abuse and to improve our understanding of the way in which drugs act as reinforcers leading to their self-administration. Plans for professional growth include advanced study in the fields of neuroendocrinology, magnetic resonance imaging and magnetic resonance spectroscopy.

该研究在此竞争的续订申请中提出的研究 研究科学家奖基于NIDA和NIDA目前资助的赠款 NIAAA专注于对妇女和女性恒河校滥用多药的研究 猴。 多药的实验分析使用大麻的模式， 酒精和烟草将在受控研究病房下进行 具有操作行为程序的条件。 慢性的后果 将在患者和药物的灵长类动物模型中检查可卡因 滥用滥用的滥用无法影响所获得的数据。 NIDA 临床研究中心研究还将评估药物相互作用和 经前烦躁不安的作用在妇女的药物自我管理中的作用。 评估辅助药物治疗的功效和安全性 在患者和 在女恒河猴中。 NIAAA支持的研究赠款计划将检查酒精对 女性的生殖激素以及乙醇诱导的改变 神经内分泌功能可能调节 酒精。 急性酒精中毒对垂体，肾上腺和 通过使用挑衅性测试来检查性腺激素 下丘脑，垂体，卵巢和肾上腺功能。 挑衅性测试 还将采用确定酒精引起的破坏机制 在生育年龄和酒精的女性中的正常月经功能 - 诱发了绝经后妇女内分泌功能的改变。 NIDA和NIAAA都将使用多学科的方法 支持来自各种学科的研究科学家，包括 精神病学，心理学，内科，内分泌学，神经病学， 药理学，护理和社会科学将参与这些 调查。 拟议研究的总体目标是 阐明行为和生物学决定因素和后果 药物滥用并提高我们对毒品方式的理解 充当增强剂，导致他们的自我管理。 计划 专业成长包括在该领域的高级研究 神经内分泌学，磁共振成像和磁共振 光谱法。