HORIZONS IN VASCULAR BIOLOGY AND THERAPEUTICS

血管生物学和治疗学的前景

• 批准号: 6028198
• 负责人: TOM DANIEL
• 金额: $ 2.13万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6028198
• 关键词: kidney disorder; kidney function; meeting /conference /symposium; therapy; travel

Recent progress in the fields of angiogenesis, vascular gene transfer, cardiovascular diseases, cancer biology, and developmental biology emphasizes the critical role the vasculature plays in normal and pathological processes. Definition of the molecular machines that mediate vascular cell assembly, remodeling, and regression promises to inform therapies for solid tumors, tissue ischemia, and ultimately to empower targeting of specific therapies to critical sites of disease in glomerulopathies. As the first avenue of access through the vascular compartment, the endothelium is a highly specialized interface accessible to targeting with vascular bed specific drugs, recombinant molecules, viral vectors and therapeutic agents designed to alter pathological processes and consequences. Recent progress at the interface between developmental biology, tissue models for vascularization, molecular target identification and vascular gene transfer offer a platform of discovery, validation and application to define new therapies. The overall goal of the conference is to bring outstanding leaders in the area into contact with promising young investigators and trainees, to evaluate the recent progress in the field and to project future directions that may impact favorably on research efforts applied to the kidney, kidney diseases and treatment of end stage conditions that afflict renal patients. To facilitate these efforts to recruit, support and develop new researchers in this rapidly growing field, the conference will offer travel grants to young investigators and trainees who are judged appropriate based on their submission of abstracts for the conference. Special consideration will be given to women, racial/ethnic minority individuals, those with disabilities, and others underrepresented. A poster session will he held in which awardees present their work for review and discussion with the leaders in this field. The planning committee for the conference will select awardees, and the applicant organization will administer award of the travel grants. The conference will be publicized in major scientific journals (both general interest and renal community focused), on the internet, and announcements will be mailed to members of the American Society of Nephrology, the sponsoring organization.

血管生成、血管基因转移、心血管疾病、癌症生物学和发育生物学领域的最新进展强调了脉管系统在正常和病理过程中发挥的关键作用。介导血管细胞组装、重塑和回归的分子机器的定义有望为实体瘤、组织缺血的治疗提供信息，并最终使特定疗法能够针对肾小球疾病的关键部位进行靶向治疗。 作为进入血管室的第一个途径，内皮是一个高度专业化的界面，可用于靶向血管床特异性药物、重组分子、病毒载体和旨在改变病理过程和后果的治疗剂。发育生物学、血管化组织模型、分子靶标识别和血管基因转移之间的最新进展为定义新疗法提供了发现、验证和应用的平台。会议的总体目标是让该领域的杰出领导者与有前途的年轻研究人员和学员进行接触，评估该领域的最新进展，并预测可能对肾脏、肾脏疾病研究工作产生有利影响的未来方向以及治疗困扰肾脏患者的终末期病症。 为了促进在这个快速发展的领域招募、支持和培养新研究人员的努力，会议将为根据向会议提交的摘要而被认为合适的年轻研究人员和实习生提供旅费补助。 将特别考虑妇女、少数种族/族裔、残疾人和其他代表性不足的人。 他将举办海报会议，获奖者将展示他们的作品，以便与该领域的领导者进行审查和讨论。 会议筹委会将选出获奖者，申请组织将管理差旅补助金的授予。会议将在主要科学期刊（包括一般兴趣期刊和肾脏界重点期刊）和互联网上进行宣传，公告将邮寄给主办组织美国肾病学会的成员。