IMAGING OPIOID RECEPTORS IN COCAINE ADDICTION TREATMENT

可卡因成瘾治疗中阿片受体成像

• 批准号: 2898304
• 负责人: James JAMES FROST
• 金额: $ 39.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2898304
• 关键词: behavior modification; behavioral /social science; bioimaging /biomedical imaging; clinical research; cocaine; dopamine transporter; drug abuse therapy; gender difference; human subject; human therapy evaluation; image processing; imaging /visualization /scanning; ligands; magnetic resonance imaging; neurochemistry; opioid receptor; positron emission tomography; receptor binding

DESCRIPTION: (Applicant's Abstract) Cocaine abuse is a major public health problem in the United States, but little is known of the neurochemical pathways that mediate the reinforcing and other properties of cocaine. Nor is there an understanding of the neurochemical changes that accompany cessation of cocaine use following treatment. The brain's endogenous opioid system is known to play an important role in reward mechanisms and our laboratory has demonstrated by the use of C-11 carfentanil and PET scanning that regional brain mu opioid receptors are increased in relation to the degree of cocaine craving. Furthermore, we have demonstrated that following 4 weeks and 90 days monitored abstinence many cocaine addicts normalize or "reset" their increased mu opioid receptors whereas others have persistently elevated levels. We now propose to evaluate the effect of out-patient treatment of cocaine abuse on mu opioid receptors. We will compare 2 forms of treatment: contingent and non-contingent voucher management. In addition to demonstrating a link between treatment outcome and brain function, these studies will determine if measurement of regional brain opioid receptors during the course of therapy predict the long-term treatment outcome with regard to relapse to cocaine use. Results from these investigations will provide vital insights for the development and improvement of behavioral as well as medication treatment of patients with cocaine addiction. We will also separately study and analyze data from men and women patients to explore sex differences in cocaine addiction and the response to treatment. The specific aims of this proposal are: 1) Determine the effect of contingency management versus non-contingent voucher treatment on the change in regional brain mu opioid receptors and cocaine use in patients with cocaine addiction; 2) Determine the relationship between cocaine use and the change in regional brain mu opioid receptors by PET after 4 and 12 weeks of treatment in patients with cocaine addiction; and 3) Determine if there is a relationship between regional brain mu opioid receptors after 12 weeks of treatment and cocaine use after treatment.

描述：（申请人摘要） 可卡因滥用是美国的一个主要公共卫生问题，但是 对于介导强化的神经化学途径知之甚少 和可卡因的其他特性。 也没有对此的理解 停止使用可卡因后神经化学变化 治疗。 众所周知，大脑的内源性阿片类药物系统发挥着 在奖励机制中的重要作用，我们的实验室已经证明 利用C-11卡芬太尼和PET扫描发现局部脑μ阿片类药物 受体的增加与对可卡因的渴望程度有关。 此外，我们已经证明，在 4 周零 90 天之后 受监控的戒断 许多可卡因成瘾者使他们的戒瘾正常化或“重置” mu 阿片受体增加，而其他受体则持续升高 水平。 我们现在建议评估门诊治疗的效果 mu 阿片受体上的可卡因滥用。 我们将比较两种治疗形式： 或有和非或有凭证管理。 此外 这些研究证明了治疗结果与大脑功能之间的联系 研究将确定是否测量大脑区域阿片受体 在治疗过程中预测长期治疗结果 关于可卡因吸食复发的问题。 这些调查的结果将 为行为的发展和改善提供重要的见解 以及可卡因成瘾患者的药物治疗。 我们将 还分别研究和分析男性和女性患者的数据 探讨可卡因成瘾的性别差异以及对治疗的反应。 该提案的具体目标是： 1) 确定 变更时的应急管理与非应急凭证处理 区域脑 mu 阿片类受体和可卡因使用患者 可卡因成瘾； 2) 确定可卡因使用与可卡因使用之间的关系 4 周和 12 周后，通过 PET 观察局部脑 mu 阿片受体的变化 可卡因成瘾患者的治疗； 3) 确定是否存在 12周后区域脑μ阿片受体之间的关系 治疗和治疗后使用可卡因。