REDUCED CALORIES, PROLIFERATION, IMMUNITY, CANCER, AGING

减少热量、增殖、免疫力、癌症、衰老

• 批准号: 2899726
• 负责人: ROBERT A GOOD
• 金额: $ 16.01万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2899726
• 关键词: aging; autoradiography; breast neoplasms; caloric dietary content; cell growth regulation; growth factor; hepatectomy; histology; intestines; laboratory mouse; laboratory rat; liver; liver regeneration; mammary gland; neoplasm /cancer immunology; northern blottings; nutrition of aging; nutrition related neoplasm /cancer; nutrition related tag; skin

This project has as its primary focus to achieve basic understanding of the influence of undernutrition without malnutrition -- chronic energy intake restriction (CEIR) which greatly increases life span and health span of rats and of mice of long-lived, and of short-lived autoimmune- prone and cancer-prone strains. We are attempting especially to analyze the mechanisms which underlie prevention by CEIR of retrovirus-induced mammary adenocarcinoma, certain autoimmunities, vascular diseases, malignancies and immunodeficiency disorders that develop with aging in mice of certain genetically short-lived strains, as well as the immunodeficiency associated with aging in mice of some long-lived strains. Particularly, we have discovered that CEIR down-regulates (tunes down) many forms of what we call vegetative and reproduction associated cellular proliferation -- while at the same time CEIR up-regulates cellular proliferation that is associated with liver regenerative repair following partial hepatectomy. Our experiments will attempt to analyze at the molecular level in one representative long-lived and in one representative short-lived strain and in one strain of mice in which females develop mammary adenocarcinoma in high frequency, how CEIR influences expression and production of growth factors that in turn influence and control cell proliferation in mammary gland epithelium, skin and esophageal and intestinal epithelium. We will also analyze how CEIR influences the expression and production of complete hepatic growth factors and a new augmentor of liver regeneration and how these actions influence hepatic cellular regeneration after partial hepatectomy. It is our view that the influence of CEIR on these crucial vegetative and adaptive proliferations play crucial roles in the action of CEIR to prolong life, prolong the span of health and prevent development of diseases which occur with aging such as cancers and autoimmunities.

该项目的主要重点是实现对 没有营养不良的营养不良的影响 - 慢性能量 摄入限制（CEIR）大大增加了寿命和健康 长寿命和短暂的自身免疫的大鼠和小鼠的跨度 容易发生且容易发生癌症。 我们正在尝试特别分析 逆转录病毒诱导的CEIR预防的机制 乳腺腺癌，某些自身免疫，血管疾病， 随着衰老而发展的恶性肿瘤和免疫缺陷障碍 某些遗传菌株的小鼠以及 与某些长寿命菌株的小鼠衰老相关的免疫缺陷。 特别是，我们发现CEIR会下调（调节） 我们称之为营养和繁殖相关的细胞的多种形式 增殖 - 同时CEIR上调了细胞 与肝脏再生维修相关的增殖 部分肝切除术。 我们的实验将尝试在 一个代表性的长寿和一个代表性的分子水平 短寿命的菌株和女性发展的一只小鼠 高频的乳腺腺癌，CEIR如何影响表达 以及生长因子的产生又影响和控制细胞 乳腺上皮，皮肤和食管的增殖 肠上皮。 我们还将分析CEIR如何影响 表达和生产完整的肝增长因子和新的 肝脏再生的增强子以及这些动作如何影响肝 部分肝切除术后的细胞再生。 我们认为 CEIR对这些至关重要的营养和适应性增殖的影响 在CEIR延长寿命的行动中扮演至关重要的角色，延长跨度 健康并防止随着这种衰老而发生的疾病 作为癌症和自身免疫。