STRENGTHS & DEFICITS IN THE MOTOR SYSTEM OF AD PATIENTS

优势

• 批准号: 6016806
• 负责人: MALCOLM B DICK
• 金额: $ 18.56万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-29 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6016806
• 关键词: Alzheimer's disease; apraxias; clinical research; cognition; early diagnosis; functional ability; human old age (65+); human subject; limb movement; neurophysiology; neuropsychology; pathologic process; performance; psychomotor function; sensorimotor system; training; visual feedback; Alzheimer's disease; apraxias; clinical research; cognition; early diagnosis; functional ability; human old age (65+); human subject; limb movement; neurophysiology; neuropsychology; pathologic process; performance; psychomotor function; sensorimotor system; training; visual feedback

Although able to acquire and retain certain motor skills, Alzheimer's disease (AD) patients appear to have deficits at both the higher "cognitive" and lower "motoric" levels of the motor system. In this project, a series of inter-related experiments will further delineate strengths and deficits in the motor functioning of AD patients. Building on the principal investigator's previous research, the first five experiments examine the effects of various practice conditions on the acquisition, retention, and transfer of a continuous fine motor skill, a discrete gross motor skill, and a multi-segment movement task. Experimental manipulations in these studies are designed to reveal the extent to which AD patients form motor schemata. In addition to disrupting these higher level processes, AD may alter basic motor control mechanisms. Experiments 6-12 will examine motor control in both laboratory (spatial aiming) and ecologically valid (handwriting) tasks. Results of studies utilizing the spatial aiming task will help separate motor control problems due to compensatory efforts by the patient from difficulties due to the neurophysiological changes associated with AD. Four studies will utilize a handwriting assessment protocol developed by the researchers to evaluate problems in fine motor control. Following norming on healthy older adults, this protocol will be administered to a diverse sample of AD patients. In addition to clarifying the impact of AD on the complex, multi-layered motor system, the proposed studies could provide a quickly administered, non-intrusive tool for early diagnosis and charting the progression of AD. Finally, the results could be used as the basis for future motor-based intervention programs directed at improving everyday living skills in AD patients.

尽管能够获得和保留某些运动技能，但阿尔茨海默氏症 疾病（AD）患者似乎都有较高的缺陷 电机系统的“认知”和较低的“摩托车”水平。在这个 项目，一系列相互关联的实验将进一步描述 AD患者运动功能的优势和缺陷。建筑 关于首席研究者先前的研究，前五个 实验检查了各种实践条件对 连续的精细运动技能的获取，保留和转移 离散的总运动技能和多段移动任务。 这些研究中的实验操作旨在揭示 AD患者形成运动模式的程度。除了破坏 这些更高级别的过程，AD可能会改变基本的运动控制机制。 实验6-12将检查两个实验室的运动控制（空间 瞄准）和生态有效（手写）任务。研究结果 利用空间瞄准任务将有助于分开电动机控制 由于患者的补偿工作而引起的问题 与AD相关的神经生理变化。将四个研究 利用研究人员制定的手写评估协议 评估精细运动控制的问题。遵循健康规范 老年人，该方案将用于多种AD样本 患者。除了阐明AD对复合体的影响外， 多层电机系统，拟议的研究可以快速提供 管理，非侵入性工具，用于早期诊断和绘制 AD的进展。最后，结果可以用作 未来基于运动的干预计划，旨在每天改善 广告患者的生活技能。