TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO

潜在药物的毒理学评价

• 批准号: 6158415
• 负责人: GERALD J SCHAEFER
• 金额: $ 25万
• 依托单位: MPI RESEARCH, LLC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6158415
• 关键词: Primates; Rodentias; dogs; dosage; drug abuse; drug abuse chemotherapy; drug screening /evaluation; gastrointestinal motility /pressure; kidney function; pharmacokinetics; toxicology

The contract will include evaluations of the compound's acute and repeat dose toxicity in rodents, dogs and/or primates. In addition, studies to determine the compound's effect on GI motility and renal function, and the compound's genotoxicity may also be conducted. The evaluations of safety/toxicity of drugs will be conducted under the GLP regulations of the FDA.

该合同将包括对啮齿动物，狗和/或灵长类动物的急性和重复剂量毒性的评估。 此外，还可以进行确定化合物对胃肠道运动和肾功能的影响以及化合物的遗传毒性的研究。 药物安全/毒性的评估将根据FDA的GLP法规进行。