Engineering Functional Antimicrobial Polypeptide Surfaces

工程功能性抗菌多肽表面

• 批准号: DP240102343
• 负责人: Prof Frank Caruso
• 金额: $ 42.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102343
• 关键词: Engineering; Functional; Antimicrobial; Polypeptide; Surfaces

Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.

抗菌涂层对于防止细菌污染至关重要，但最近开发的结构纳米工程抗菌肽聚合物（SNAPP）尚不存在，为了将其应用扩展到一系列表面的抗菌涂层中。通过开发酚醛功能化 SNAPP，该项目旨在利用金属酚醛材料的粘合性质来快速涂覆各种表面，包括不锈钢。预期成果是抗菌多肽表面的产生，这将有利于食品安全、医疗植入技术和先进纺织品。