CORTICAL MECHANISMS OF MOTOR PROCESSING

运动处理的皮质机制

• 批准号: 2891821
• 负责人: MICHAEL D CRUTCHER
• 金额: $ 20.87万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891821
• 关键词: Macaca mulatta; behavior test; brain electrical activity; electromyography; limb movement; motion perception; motor cortex; neural information processing; neuromuscular function; psychomotor function; space perception; visual stimulus; visual tracking

DESCRIPTION (Adapted from Applicant's Abstract): The broad, long-term objectives of our research are to: 1) determine how the central nervous system (CNS) controls visually-guided limb movements by identifying neural activity related to the behavioral processes and variables that underlie such movements, and 2) characterize the specialized functional roles of different cortical motor areas in the control of movement. The current proposal is based upon the results of single cell recording studies which found evidence that several different types of neural activity related to the early stages of vasomotor processing are located in the cortical motor areas of monkeys performing visually-guided tracking tasks. These include activity related independently to: 1) which visual target is captured, 2) the direction of Specific Aim 1: To test the hypothesis that there is a differential distribution of target-independent activity in the four premotor areas. The results of this study will provide new information about the extent to which these four premotor areas participate in early stages of vasomotor transformations. Specific Aim 2: To test the hypothesis that target-dependent activity is a neural correlate of visually guided-limb movements. An oculomotor delayed response task will be used to verify that target-dependent activity is contingent upon the execution of limb and/or cursor movements. This task will provide convincing evidence that the previously observed target-dependent activity is indeed related to high-level aspects of vasomotor transformations. Specific Aim 3: To test the hypothesis that there are neurons in these four premotor areas whose activity is related independently to 1) the target captured by the cursor, 2) the director of cursor movement, or 3) the endpoint of hand/joystick movement. Since the equilibrium point hypothesis and analytical models of motor processing would make different predictions regarding the occurrence of these different patterns of activity, the results of these studies will provide evidence regarding the plausibility of these two models of vasomotor processing.

描述（改编自申请人的摘要）：广泛的长期 我们研究的目标是：1）确定中枢神经如何 系统（CNS）通过识别神经来控制视觉引导的肢体运动 与行为过程和变量有关的活动 这样的动作，以及2）表征 控制运动中的不同皮层运动区域。 电流 建议基于单细胞记录研究的结果 发现证据表明几种不同类型的神经活动与 血管舒缩处理的早期阶段位于皮质电机中 猴子执行视觉引导跟踪任务的区域。 这些包括 独立相关的活动与：1）捕获哪个视觉目标，2） 特定目的的方向1：检验有一个假说 四个目标非依赖性活动的差分分布 前区域。 这项研究的结果将提供新信息 关于这四个前运动区参与的程度 血管舒缩变换的阶段。 特定目的2：检验目标依赖性活动的假设是 视觉引导的LIMB运动的神经相关性。 动眼延迟 响应任务将用于验证目标依赖性活动是 取决于执行肢体和/或光标运动。 这个任务 将提供令人信服的证据表明先前观察到的 目标依赖性活动确实与高级方面有关 血管舒适转换。 特定目的3：测试这四个神经元的假设 活动与活动独立相关的前者区域1​​） 由光标捕获，2）光标运动主任，或3） 手/操纵杆运动的终点。 由于平衡点假设 电机处理的分析模型将做出不同的预测 关于这些不同的活动模式的发生， 这些研究的结果将提供有关合理性的证据 这两种模型的血管舒缩处理。