ISOPRENE, INDIUM PHOSPHIDE, GALLIUM ARSENIDE

异戊二烯、磷化铟、砷化镓

• 批准号: 2874371
• 负责人: BILLY J CHOU
• 金额: --
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1988-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2874371
• 关键词: arsenic; clinical chemistry; gallium; glutaraldehyde; hematology; indium; laboratory mouse; laboratory rat; organic chemicals; physical chemical interaction

The objective of this project is to determine the potential toxicity and carcinogenicity of isoprene, indium phosphide, gallium arsenide, and optionally glutaraldehyde, by inhalation to Fischer 344 rats and B6C3Fl mice. The basic award for each chemical includes the development of analytical chemistry and generation and monitoring methods. Once these methods have been adequately developed, toxicity/carcinogenicity studies are to be conducted. Isoprene: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure. Indium phosphide: 13-week study is to be conducted, involving ten animals/sex/species, at 5 exposure concentrations plus controls; hematology and clinical chemistry in rats, hematology in mice; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of indium concentrations in whole blood, serum, testes and lung. 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; determination of indium concentrations in whole blood, serum, testes and lung. Gallium arsenide: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of gallium and arsenic concentrations in whole blood, serum, testes and lung. Optional study of Glutaraldehyde: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls.

该项目的目的是确定潜在的毒性和 异戊二烯，磷化二磷脂，砷耐加仑和的致癌性 可选的是戊二醛，吸入Fischer 344只大鼠和B6C3FL 老鼠。 每种化学物质的基本奖项包括开发 分析化学以及生成和监测方法。 一旦这些 方法已经充分开发了，毒​​性/致癌性研究 要进行。 异戊二烯：将进行104周的研究，涉及五十周 动物/性别/物种，在3个暴露浓度和对照中；体内 在大鼠和小鼠的遗传毒性研究中 接触。 磷化抑制剂：将进行13周的研究，涉及十个 动物/性别/物种，在5个暴露浓度和对照中； 大鼠的血液学和临床化学，小鼠血液学；体内 在大鼠和小鼠的遗传毒性研究中 接触;确定全血，血清中尊浓度的浓度 睾丸和肺。 将进行104周的研究，涉及五十只动物/性别/物种 在3个暴露浓度和对照处；确定抑制 全血，血清，睾丸和肺的浓度。 砷耐加仑：将进行104周的研究，涉及五十周 动物/性别/物种，在3个暴露浓度和对照中；体内 在大鼠和小鼠的遗传毒性研究中 接触;整体凝固型和砷浓度的测定 血液，血清，睾丸和肺部。 戊二醛的可选研究：将进行104周的研究， 涉及五十只动物/性别/物种，以3次暴露浓度加上 控件。