ROCKY MOUNTAIN CANCER GENETICS COALITION

落基山癌症遗传学联盟

• 批准号: 2896519
• 负责人: RAYMOND L WHITE
• 金额: $ 101.96万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896519
• 关键词: breast neoplasms; cancer information system; cancer registry /resource; clinical research; colorectal neoplasms; cooperative study; data management; family genetics; gene expression; genetic counseling; genetic mapping; genetic susceptibility; human genetic material tag; human subject; neoplasm /cancer epidemiology; neoplasm /cancer genetics; prostate neoplasms; questionnaires

DESCRIPTION: (Applicant's Description) Inherited predispositions to specific cancers due to high penetrance alleles of genes such as APC and BRCA1 account for only a small percentage of our populations cancer burden. Genetic epidemiological evidence suggests, however, that a much higher percentage of individuals may be at risk due to the inheritance of alleles, or combinations of alleles, that individually show only a relatively low cancer penetrance. This makes it difficult to analyze the associated patterns of inheritance, localize the loci and identify the specific genes involved. Large sample populations are now required to map and identify these genes. We propose establishing a consortium consisting of the Universities of Colorado, New Mexico and Utah whose primary purpose will be to enroll a study population and create an infrastructure to support this next generation of exploration of the genetics of cancer. A population-based approach is needed to understand the population significance of future findings. State cancer registries provide an appropriate avenue of ascertainment. It is also important to develop a study population enriched for predisposed individuals. Our approach, therefore, is to ascertain individuals with one or more relatives who have been diagnosed with the specific cancer. Specifically, we propose initially to contact each individual diagnosed with breast, prostate, or colorectal cancer in calendar 1998 and 1999 and determine: 1) whether they are willing to participate and 2) have first-degree relatives affected with their same cancer. If so, they will be recontacted and asked to provide more detailed information regarding family history, as well as demographic and epidemiologic information. Selected index cases will be requested to complete questionnaires, which will include the names of their first-degree relatives and their permission to contact these relatives. The first-degree relatives will then be contacted and invited to enroll as members of the Cancer Genetics Network. This approach will create a study population of family members who have had cancer and who are at risk for cancer. We will also offer enrollment to appropriate individuals who have already contacted our high-risk clinics or are enrolled in ongoing clinical protocols of familial cancer; for example, Colorado will extend their current research interests by collecting lung cases. In addition, we will establish or enhance clinical and laboratory core facilities, as well as the necessary capabilities in genetic counseling, informatics and database management. As study groups are enrolled, DNA samples may be collected and pilot projects initiated; these include sib-pair studies and candidate-gene analysis funded by the Huntsman Cancer Institute and the University of Colorado Cancer Center.

描述：（申请人的描述）继承的倾向 由于基因的高渗透等位基因，例如APC和 BRCA1仅占癌症负担的一小部分。 但是，遗传流行病学证据表明，更高 由于等位基因的继承，个人的百分比可能处于危险之中， 或等位基因的组合，单独显示相对较低 癌症的渗透率。 这使得很难分析相关的 继承模式，定位基因座并识别特定基因 涉及。 现在需要大量样本人群来映射和识别 这些基因。 我们建议建立一个由 科罗拉多大学，新墨西哥州和犹他州的主要目的是 注册研究人群并建立基础设施来支持这一点 癌症遗传学的下一代探索。 一个 需要基于人群的方法来了解人口 未来发现的意义。 州癌症注册表提供了 适当的确定途径。 开发一个也很重要 研究人群丰富了诱发的个体。 我们的方法， 因此，是要确定一个或多个有亲戚的人 被诊断为特定癌症。 具体来说，我们最初建议 联系每个被诊断为乳房，前列腺或结直肠肠的人 1998年和1999年日历中的癌症，并确定：1）他们是否愿意 参与和2）拥有一级亲戚。 癌症。 如果是这样，他们将被重新连接，并要求提供更详细的信息 有关家族史以及人群和人群的信息 流行病学信息。 选定的索引案例将要求 完整的问卷，其中包括其一级名称 亲戚及其与这些亲戚联系的许可。 一级 然后，将联系亲戚并邀请作为成员 癌症遗传学网络。 这种方法将创建一个研究人群 患有癌症并且有癌症风险的家庭成员。 我们将 还向已经联系的适当个人提供注册 我们的高风险诊所或正在进行正在进行的临床方案 家族癌；例如，科罗拉多州将扩展他们当前的研究 通过收集肺病例的利益。 此外，我们将建立或 增强临床和实验室核心设施，以及必要的 遗传咨询，信息学和数据库管理的能力。 作为 研究组已注册，可以收集DNA样本并进行试点项目 发起；这些包括资助的SIB-PAIR研究和候选基因分析 亨斯曼癌症研究所和科罗拉多大学癌症 中心。