EPIDEMIOLOGY OF AEMND--A POSSIBLE MODEL FOR ALS

AEMND 的流行病学——ALS 的可能模型

• 批准号: 2267800
• 负责人: HUSSNI O MOHAMMED
• 金额: $ 10.43万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2267800
• 关键词: amyotrophic lateral sclerosis; animal age group; animal ecology; animal population study; aspartate transaminase; atomic absorption spectrometry; axon reaction; blood chemistry; cellular pathology; creatine kinase; degenerative motor system disease; disease /disorder model; disease /disorder proneness /risk; electron microscopy; enzyme activity; epidemiology; fluorescence spectrometry; gas chromatography mass spectrometry; histopathology; horses; interview; longitudinal animal study; molecular pathology; motor neurons; neurologic manifestations; organelles; pathologic process; questionnaires; sex; statistics /biometry; thin layer chromatography; urinalysis

Acquired equine motor neuron disease (AEMND) is a newly described disease in horse. AEMND is characterized by clinical symptoms of progressive weakness, weight loss, muscle fasiculations, muscle atrophy, and elevated serum creatine phosphokinase. These clinical symptoms coupled with the pathologic depiction of neural degenerative changes are very similar to those described in humans affected with sporadic amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease. Therefore, this study may be used as an animal model for ALS to obtain insight into the etiology, pathogenesis and biochemical mechanisms underlying the human disorders. Previous animal models failed to provide new information to understand ALS because they were either experimental models based on hypothesized etiologic factor or hereditary models that were based on hypotheses which the investigators failed to prove. However, AEMND in horses is advantageous to previous models due to the similarities in clinical signs and pathological lesions between the condition (AEMND) and ALS. We proposed this study to fully describe the distribution of the neurologic changes and determine the rate of occurrence of newly described acquired equine motor neuron disease (AEMND) in horses in the Northeast of the US. We also are planning to identify risk factors associated with this disease and quantifying their risk on the likelihood of developing AEMN. The epidemiologic study of choice is the ambidirectional design. This design, also referred to as nested case- control design, combines elements of cohort and case-control epidemiologic study designs. We will identify the horse population in the Northeast, US and follow them for 5 years. Suspected cases will be examined pathologically for confirmation and additional description of the neurodegenerative changes at New York State College of Veterinary Medicine (NYSCVM). The rate of occurrence of AEMND will then be determined. Noncases (controls) will also be selected from the horse population from which a AEMND case was identified. A comparison between cases and noncases with respect to the putative risk factors will then be made. These risk factors include intrinsic factors (age, sex, breed), health (disease history), management (husbandry, nutrition), and environmental factors (location, toxins, heavy metals, ...etc). Multivariate statistical techniques (logistic regression) will be used to identify risk factors significantly associated with the likelihood of developing AEMND while controlling simultaneously for other possible risk factors.

获得性马运动神经元病（AEMND）是一种新描述的疾病 在马。 AEMND 的特点是进行性临床症状 虚弱、体重减轻、肌肉颤动、肌肉萎缩和血压升高 血清肌酸磷酸激酶。 这些临床症状与 神经退行性改变的病理描述与 那些在患有散发性肌萎缩侧索硬化症的人类中所描述的 硬化症 (ALS) 或卢伽雷氏病。 因此，本研究可能是 用作 ALS 动物模型以深入了解病因， 人类疾病的发病机制和生化机制。 以前的动物模型未能提供新的信息来理解 ALS 因为它们要么是基于假设的实验模型 基于以下假设的病因或遗传模型 调查人员未能证明。 然而，马的 AEMND 是 由于临床症状相似，优于以前的模型 以及病情 (AEMND) 和 ALS 之间的病理病变。 我们提出这项研究是为了全面描述 神经系统变化并确定新的发生率 描述了马的获得性马运动神经元病（AEMND） 美国东北部。 我们还计划确定风险因素 与这种疾病相关并量化其风险的可能性 开发 AEMN。 选择的流行病学研究是 双向设计。 这种设计，也称为嵌套案例 - 对照设计，结合队列和病例对照的元素 流行病学研究设计。 我们将确定马的数量 美国东北部并跟踪他们 5 年。 疑似病例将 进行病理学检查以确认和补充描述 纽约州立兽医学院的神经退行性变化 医学（NYSCVM）。 AEMND 的发生率为 决定。 非案例（对照）也将从马中选择 发现 AEMND 病例的人群。 之间的比较 与假定的风险因素相关的案例和非案例将被 制成。 这些风险因素包括内在因素（年龄、性别、品种）、 健康（疾病史）、管理（畜牧、营养）和 环境因素（位置、毒素、重金属等）。 多元统计技术（逻辑回归）将用于 识别与发生可能性显着相关的风险因素 开发 AEMND，同时控制其他可能的风险 因素。