CORTICAL MECHANISMS FOR OLFACTORY DISCRIMINATION

嗅觉辨别的皮质机制

• 批准号: 2471000
• 负责人: LEWIS B HABERLY
• 金额: $ 23.65万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-15 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2471000
• 关键词: afferent nerve; brain mapping; chemoreceptors; fatty acids; laboratory rat; lateral olfactory area; limbic system; neural information processing; olfactions; olfactory stimulus; sensory discrimination

DESCRIPTION (Adapted from the Investigator's Abstract): In the past few years a series of fundamental-level advances have been made in our understanding of the olfactory system at the receptor level, and at the initial stage of central processing in the olfactory bulb. However, it is probably fair to say that none of the fundamental questions have been answered concerning how the olfactory cortex participates in further processing, despite the existence of a rather detailed 'circuit diagram' for piriform cortex (the largest subdivision of olfactory cortex), and the existence of considerable data on responses to odorants in piriform cortex recorded with a variety of techniques in several species. The comparative lack of progress and interest in olfactory cortex is surprising in view of the relative ease with which this highly laminated system can be studied, the strong arguments for its usefulness as a model to study questions of a general nature concerning cortical function, and the fact that operation of the olfactory bulb clearly cannot be understood in isolation from the cortex in view of the return projection it receives from the cortex that is an order of magnitude heavier than it's output projection to the cortex. The basic rationale for the proposed research program is that, although separate analyses of neuronal circuitry and odor responses in piriform cortex have failed to provide insights into mechanisms of its operation, a carefully designed combination of both approaches will provide a powerful analytical tool. The specific aims will test a series of predictions from the hypothesis that piriform cortex contains both spatial and ensemble representations of odor quality in different subdivisions, and that the ensemble representation enables powerful analysis, memory, and associative functions via"parallel-distributed" processes similar to those developed in studies of artificial networks. The experiments will use an integrated approach in which the recording of responses to odorants will be coordinate with anatomical analysis of the connections of single cells and functional groups of cells.

描述（改编自调查员的摘要）：在过去的几个 多年来，我们的一系列基本层面的进步已在我们的 了解受体水平和在 嗅球中中央加工的初始阶段。 但是，是 可以说，没有一个基本问题 回答了有关嗅觉如何进一步参与的如何参与 处理，尽管存在相当详细的“电路图” 梨状皮层（嗅皮层的最大细分）和 存在有关梨状皮层中气味响应的大量数据 在几种物种中使用多种技术记录。 比较 鉴于 可以研究这种高度层压系统的相对容易性， 强烈的论点是它作为研究一个问题的模型的有用性 关于皮质功能的一般性质，以及 显然不能从皮质孤立地理解嗅球 鉴于它从皮质中收到的返回投影是一个 比对皮质的输出投影重的数量级。 这 拟议的研究计划的基本基本原理是，尽管 梨状皮层中神经元电路和气味反应的分析 未能提供有关其操作机制的见解，仔细的 两种方法的设计组合都将提供强大的分析 工具。 具体目的将测试一系列预测 假设梨状皮层包含空间和合奏 在不同细分中的气味质量的表示， 合奏表示可以实现强大的分析，内存和关联 通过“并行分配”过程的功能，类似于开发的过程 人工网络的研究。 实验将使用集成的 记录对气味的响应将是坐标的方法 通过解剖分析单细胞和功能的连接 细胞组。