CORE--NEUROBEHAVIOR

核心--神经行为

• 批准号: 6273581
• 负责人: PHILIP M MC CABE
• 金额: $ 15.22万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6273581
• 关键词: behavioral /social science research tag; biomedical facility; cerebral ischemia /hypoxia; cerebrovascular occlusions; disease /disorder model; ethology; laboratory rat; neuropsychological tests; neuropsychology; nonhuman therapy evaluation; sensorimotor system

The purpose of Core E is to: a) provide quantitative analyses of the behavioral correlates of cerebral ischemia in animal models; b) assess long-term recovery of function following ischemia; and c) evaluate therapeutic strategies for treatment of cerebral ischemia using behavioral outcomes. In each case, behavioral measures will be correlated with morphological sequelae of cerebral ischemia (see Projects 1-4). Behavioral paradigms were designed to assess functional deficits associated with three different animal models of cerebral ischemia: 1) photochemical infarction of the somatosensory cortex in rats (see Project 2); 2) global cerebral ischemia induce by either 2-vessel or 4-vessel occlusion in rats (see Projects 3 & 4 and Core C-1); and 3) brain injury resulting from occlusion of the middle cerebral artery in rats (see Project 1).

核心E的目的是：a）提供定量分析 动物模型中脑缺血的行为相关性； b）评估 缺血之后的功能的长期恢复；和c）评估 使用治疗脑缺血治疗的治疗策略 行为结果。 在每种情况下，行为措施将是 与脑缺血的形态后遗症相关（请参阅项目 1-4）。 行为范例旨在评估功能不足 与三种不同动物脑缺血模型有关：1） 大鼠体感皮质的光化学梗塞（请参阅项目 2）; 2）全球脑缺血由2个血管或4卷赛诱导 大鼠的闭塞（请参阅项目3和4和Core C-1）； 3）脑损伤 由大鼠中大脑中动脉的阻塞导致 项目1）。