AEROBIC EXERCISE IN CYSTIC FIBROSIS

囊性纤维化的有氧运动

• 批准号: 2229616
• 负责人: DAVID M ORENSTEIN
• 金额: $ 68.07万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2229616
• 关键词: adolescence (12-20); behavioral medicine; cystic fibrosis; exercise; gender difference; health service demonstration project; home health care; human mortality; human subject; human therapy evaluation; monitoring device; physical fitness; quality of life; rehabilitation; respiratory function; therapy compliance

Cystic fibrosis (CF) is the most common inherited life-shortening disease among white populations, and is characterized by progressive loss of pulmonary function, exercise tolerance, and quality of life. Previous short-term studies have shown that patients with CF may benefit from aerobic exercise, with improved cardiopulmonary fitness, exercise tolerance, and perhaps either improvement or delay in the expected deterioration in lung function. Recent observations have confirmed a strong correlation between aerobic fitness and survival in patients with CF There have been no published studies that used behavioral medicine techniques to secure compliance with a long-term aerobic exercise program for patients with CF, aged 8 - 18 years, to see if the benefits, particularly the increase in aerobic fitness, seen with short programs could be sustained. This proposal would institute a controlled randomized study of one year of at-home aerobic exercise (stair-stepping) compared with at-home upper body weight-lifting exercise (that is unlikely to increase aerobic fitness) for patients with CF. The study design incorporates state-of-the-art behavioral medicine techniques and a strong money-based incentive system to secure patients' continued participation. The effects of such a program on aerobic fitness (measured as peak oxygen consumption), exercise tolerance, pulmonary function, upper body strength, and quality of life will be measured. This intervention has the potential to increase CF patients' fitness, pulmonary function, life-quality, and even longevity.

囊性纤维化（CF）是最常见的遗传性缩短寿命疾病 在白人群体中，其特点是逐渐丧失 肺功能、运动耐量和生活质量。 以前的 短期研究表明，CF 患者可能受益于 有氧运动，增强心肺功能，锻炼身体 容忍度，也许是预期的改善或延迟 肺功能恶化。 最近的观察证实了 有氧运动与患者生存率之间存在很强的相关性 CF 尚未发表使用行为医学的研究 确保遵守长期有氧运动计划的技术 对于年龄 8 - 18 岁的 CF 患者，看看是否有好处， 尤其是短程训练中有氧运动能力的提高 可以持续。该提案将建立一个受控随机 一年在家有氧运动（爬楼梯）的研究比较 在家进行上半身举重锻炼（不太可能 增加有氧运动）CF 患者。 研究设计 结合了最先进的行为医学技术和强大的 以金钱为基础的激励制度，以确保患者的持续参与。 此类计划对有氧健身的影响（以峰值氧气测量） 消耗）、运动耐量、肺功能、上半身力量、 并将衡量生活质量。 这种干预有潜力 提高 CF 患者的体能、肺功能、生活质量和 甚至长寿。