MECHANISMS UNDERLYING CORTICAL PLASTICITY

皮质可塑性的机制

基本信息

批准号：
2771927
负责人：
KEVIN FOX
金额：
$ 8.43万
依托单位：
CARDIFF UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-08-01 至 1999-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2771927
关键词：
behavioral genetics cAMP response element binding protein calmodulin dependent protein kinase cerebral cortex developmental genetics enzyme activity gene deletion mutation laboratory mouse laboratory rat long term potentiation neural inhibition neural plasticity synapses vibrissae

项目摘要

DESCRIPTION: (Applicant's abstract) The goal of the proposed experiments is to understand the mechanisms and rules which govern modification of synaptic strength in the cerebral cortex throughout life. Five hypotheses are proposed. First, the cortical depression mechanisms are active not passive. To address this question, changes in neuronal activity in vibrissa representation in the barrel cortex caused by uni- vibrissa deprivation (removing all but a single vibrissa) will be studied. Second, cortical depression mechanisms are caused by heterosynaptic interactions. To address the hypothesis, cortical activity will be studied and compared in animals with a single vibrissa deprived and all vibrissae are deprived. Third, cortical potentiation mechanisms are associated not competitive in adults and adolescents. Forth, cortical potentiation mechanisms require CAMKII in adults but not adolescents. Fifth, long term changes in cortical plasticity require protein synthesis via CREB. In these two sets of experiments, the mouse barrel cortical activities of CAMKII and CREB knockout mice will be investigated.

描述：（申请人的摘要）拟议实验的目标是了解控制修改的机制和规则一生中大脑皮层的突触力。五提出了假设。首先，皮质抑郁机制是主动不被动。为了解决这个问题，神经元的变化由单杆引起的枪管皮层中颤音的活性 Vibrissa剥夺（除了单个颤音以外的全部）将是研究。其次，皮质抑郁机制是由异突触相互作用。为了解决假设，皮质将在具有单个颤音的动物中研究和比较活动被剥夺和所有颤音被剥夺。第三，皮质增强在成年人和青少年中，机制不具有竞争力。第四，皮质增强机制需要成人CAMKII，但不需要青少年。第五，长期的皮质可塑性变化需要通过CREB合成蛋白质。在这两组实验中，鼠标 Camkii和Creb淘汰小鼠的桶皮层活动将是调查。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of cortical activity in experience-dependent potentiation and depression of sensory responses in rat barrel cortex.

皮质活动在大鼠桶状皮层感觉反应的经验依赖性增强和抑制中的作用。

DOI：
10.1523/jneurosci.21-11-03881.2001
发表时间：
2001
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Wallace,H;Glazewski,S;Liming,K;Fox,K
通讯作者：
Fox,K

The effect of vibrissa deprivation pattern on the form of plasticity induced in rat barrel cortex.

触须剥夺模式对大鼠桶状皮层诱导的可塑性形式的影响。