EVALUATION OF NIDDM RISK FACTORS IN THE CHEROKEES

切罗基人 NIDDM 风险因素的评估

• 批准号: 2858374
• 负责人: ELISA TAN LEE
• 金额: $ 1.94万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2858374
• 关键词: Native Americans; age difference; blood chemistry; blood lipoprotein; body physical activity; cardiovascular disorder; child (0-11); data collection methodology /evaluation; diabetes education; diet; disease /disorder prevention /control; disease /disorder proneness /risk; family genetics; glucose tolerance; health economics; human subject; longitudinal human study; medical complication; noninsulin dependent diabetes mellitus; nutrition related tag; obesity; questionnaires; statistics /biometry; young adult human (21-34)

Diabetes, particularly non-insulin dependent diabetes mellitus (NIDDM), and its complications have become an increasingly important health problem for many American Indian populations. Data on the progression of NIDDM risk factors from early ages are scarce. This application proposes an epidemiologic study to evaluate a number of potential risk factors for NIDDM among members of the Cherokee Nation of Oklahoma. A stratified sample of subjects will be taken across a wide range of ages and degrees of Indian blood from childhood to adulthood. Some of these risk factors are also related to cardiovascular disease, a major complication of diabetes. The study will use a pseudo-cohort design to evaluate fasting glucose and insulin, glucose tolerance, and a number of potential risk factors for NIDDM (and cardiovascular disease), such as family history of diabetes, degree of Indian blood, obesity, diet, lipids and lipoproteins, physical activity, and social and economic factors, in the Cherokees aged 5 to 40 years. The major objectives are (1) to estimate the prevalence of obesity, impaired glucose tolerance (IGT), and diabetes in Cherokees less than 40 years of age, (2) to estimate the progressive differences in these variables from childhood to adulthood, (3) to determine the relationships between the risk factors and fasting glucose and insulin, and glucose tolerance at different ages and whether the relationships vary with age, (4) to estimate the age ranges in which obesity, elevated fasting glucose, glucose intolerance, insulin resistance, and abnormal lipids and lipoproteins occur, (5) to determine the effect of degree of Indian blood on fasting glucose, insulin, glucose intolerance, and other potential risk factors for NIDDM (and CVD), and (6) based on the information obtained, to recommend educational programs and other timely preventive measures and, consequently, reduce the burden of diabetes and improve the health status of American Indians. A pilot study of 218 participants was completed in 1992 with a planning grant from NIDDK. Through the pilot study, logistics of blood sample collection, transport, assay, and data collection and analysis have been worked out. Estimates of risk factors determined from the results of the pilot study facilitated sample size determination. The Cherokee Nation is selected as the study population because of its high prevalence of diabetes, varying degree of Indian blood, large membership, excellent health care facilities, and strong interest in research among the leaders and health professionals.

糖尿病，尤其是非胰岛素依赖性糖尿病（NIDDM）， 它的并发症已成为越来越重要的健康 许多美洲印第安人人口的问题。关于进展的数据 NIDDM早期的风险因素很少。此申请提出 一项流行病学研究，以评估许多潜在的风险因素 NIDDM是俄克拉荷马州切诺基国家的成员。一个分层 受试者的样本将在各种年龄和度上遍及程度 从童年到成年的印度血液。其中一些风险因素 也与心血管疾病有关，这是 糖尿病。 这项研究将使用伪孔设计来评估禁食葡萄糖和 胰岛素，葡萄糖耐受性以及许多潜在的风险因素 NIDDM（和心血管疾病），例如糖尿病家族史， 印度血液，肥胖，饮食，脂质和脂蛋白的程度，物理 5至40岁的切诺基人的活动以及社会和经济因素 年。主要目标是（1）估计 肥胖，葡萄糖耐量受损（IGT）和切诺基糖尿病较少 超过40岁，（2）估计 这些变量从童年到成年，（3）确定 风险因素与空腹葡萄糖和胰岛素之间的关系， 以及不同年龄的葡萄糖耐量以及关系是否 随着年龄的增长而变化，（4）估计年龄范围肥胖升高 禁食葡萄糖，葡萄糖不耐症，胰岛素抵抗和异常 发生脂质和脂蛋白，（5）确定程度的影响 印度血液上的空腹葡萄糖，胰岛素，葡萄糖不耐症和其他血液 NIDDM（和CVD）的潜在危险因素，以及（6）基于 获得的信息，推荐教育计划和其他及时 预防措施，因此减轻了糖尿病的负担 改善美洲印第安人的健康状况。 一项对218名参与者的试点研究于1992年完成了计划 从NIDDK获得赠款。通过试点研究，血液样本的物流 收集，运输，测定和数据收集和分析已经 锻炼了。估计从从 试点研究促进了样本量的确定。 切诺基国家被选为研究人群 糖尿病患病率很高，印度血液的不同程度 会员资格，优秀的医疗保健设施以及对 领导者和卫生专业人员之间的研究。