GLUTAMINE METABOLISM IN HUMAN NEONATES

人类新生儿的谷氨酰胺代谢

• 批准号: 6279075
• 负责人: Brenda Poindexter
• 金额: $ 1.68万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279075
• 关键词: aminoacid biosynthesis; aminoacid metabolism; clinical research; dietary supplements; glutamine; human subject; newborn human (0-6 weeks); nutrition related tag; physiologic stressor; premature infant human; stress; surgery

The overall objective of this proposal is to elucidate the pathways of glutamine metabolism in neonates and to determine how prematurity and surgical stress alter these pathways. Glutamine, an important fuel for lymphocytes and intestinal epithelial cells, may be an indispensable amino acid in premature and surgically stressed infants. Consequently, determining the capacity of these infants to synthesize glutamine and the regulation of the release of glutamine from existing body protein is important. Glutamine supplementation may play a critical role in supporting optimal protein accretion, recovery from intestinal injury, and immune function in these particularly vulnerable infants. The specific aims of this proposal are to determine how rates of de novo glutamine synthesis and release of glutamine from body protein are altered by prematurity and surgical stress in: 1) the basal state 2) in response to the provision of parenteral nutrition and 3) in response to the provision of parenteral nutrition with supplemental glutamine. These specific aims will be pursued using stable isotope tracers. Performing these studies will provide insight into the metabolism of glutamine and ultimately, may serve as the basis for improved nutritional management of premature and surgically stressed infants.

该提案的总体目标是阐明 新生儿的谷氨酰胺代谢并确定早产和 手术应激改变了这些途径。 谷氨酰胺，重要的燃料 淋巴细胞和肠上皮细胞，可能是不可缺少的氨基 早产儿和手术应激婴儿的酸。 最后， 确定这些婴儿合成谷氨酰胺的能力和 从现有的身体蛋白质中释放谷氨酰胺的调节是 重要的。 补充谷氨酰胺可能发挥关键作用 支持最佳蛋白质积累、肠道损伤恢复，以及 这些特别脆弱的婴儿的免疫功能。 具体的 该提案的目的是确定从头谷氨酰胺的比率 身体蛋白质中谷氨酰胺的合成和释放被改变 早产和手术应激：1) 基础状态 2) 反应 提供肠外营养，以及 3) 响应 提供肠外营养并补充谷氨酰胺。 这些 将使用稳定同位素示踪剂来实现具体目标。 表演 这些研究将深入了解谷氨酰胺的代谢和 最终，可以作为改善营养管理的基础 早产儿和手术应激的婴儿。