NSABP MEMBER--MICHIGAN STATE UNIVERSITY

NSABP 会员--密歇根州立大学

• 批准号: 2653972
• 负责人: NIKOLAY V DIMITROV
• 金额: $ 30.35万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-12-12 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2653972
• 关键词: Corynebacterium; antineoplastic antibiotics; biological response modifiers; biopsy; breast neoplasm /cancer diagnosis; breast neoplasms; breast surgery; clinical research; clinical trials; colorectal neoplasms; combination cancer therapy; combination chemotherapy; cooperative study; data collection; doxorubicin; estrogen inhibitor; estrogens; fluorouracil; hormone receptor; hormone therapy; human subject; human therapy evaluation; longitudinal human study; methotrexate; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; tamoxifen

This research proposal is a part of the Primary Breast Cancer Therapy Group - NSABP. The main objective of the NSABP is to improve disease-free survival and overall survival in patients with primary operable breast and colo-rectal cancer (See the NSABP Headquarters Grant application for protocol rationale and overall scientific achievements). Michigan State University has been a member of NSABP since 1976. During the first ten years, the satellites, campuses in the state of Michigan, formed a strong consortium with the nucleus at the main campus. At the present time, we are treating and following 953 patients on long-term NSABP adjuvant protocols. We expect to increase our accrual to 160 (30%) patients per year which will increase substantially the number of follow-up patients during the next five years. Five new oncologists trained in clinical trials joined our community campuses. They will contribute to the increase of the accrual. Our outreach program has been a major contributor to NSABP clinical trials during the last years. Besides our efforts to accrue patients to NSABP protocols, our members participated actively in the scientific activities of the group as chair of the Committee of Biologics in Diagnosis and Treatment of Breast Cancer, Colon Committee, and organized and planned group scientific programs. The PI participates actively in the design of the pilot studies. Having a well developed laboratory equipped with HPLC, GLC and Mass Spectroscopy apparatuses, our institution will offer to the group additional studies related to drug and hormone metabolites. We have and will continue to participate actively in the group meetings. The PI has been on the executive committee of the group for the last five years and one of the nurses on the Nursing Committee for the last six years. We are contributing to the Audit Program of the group with two nurses assigned to auditing teams. Three physicians have participated in recent publications of manuscripts and abstracts presented to ASCO meetings. We intend to increase this activity. The PI has actively participated in numerous NCI site visits and peer review committees. Our institution has a special program to foster and monitor accrual of ethnic minorities to NSABP trials. We have a unique organization for accrual and execution of NSABP trials based on academic community consortium (community campuses) and the PI assumes responsibility for all activities related to the group efforts.

该研究提案是原发性乳腺癌治疗的一部分 组 - NSABP。 NSABP 的主要目标是改善无病 初次可手术乳房患者的生存率和总生存率 结直肠癌（参见 NSABP 总部拨款申请 议定书的基本原理和总体科学成就）。 密歇根州立大学 大学自 1976 年以来一直是 NSABP 的成员。在前十年期间 多年来，密歇根州的卫星校园形成了强大的 以主校区为核心的联盟。 目前，我们 正在治疗和随访 953 名接受长期 NSABP 辅助治疗的患者 协议。 我们预计将每个患者的应计人数增加到 160 名 (30%) 名患者 年，随访患者数量将大幅增加 在未来五年内。 五位新肿瘤科医生接受了临床培训 试验加入了我们的社区校园。 他们将为 应计费用的增加。 我们的外展计划是一项重要的 过去几年中 NSABP 临床试验的贡献者。 除了我们努力让患者遵守 NSABP 协议外，我们的会员 作为主席积极参与小组的科学活动 乳腺癌诊断和治疗生物制剂委员会， 结肠委员会，并组织和策划团体科学计划。 这 PI 积极参与试点研究的设计。 拥有一个 完善的实验室，配备 HPLC、GLC 和质谱仪 仪器，我们的机构将为该小组提供额外的研究 与药物和激素代谢有关。 我们已经并将继续 积极参加小组会议。 PI 已上 该集团过去五年的执行委员会成员之一 过去六年护理委员会的护士。 我们是 为该小组的审计计划做出贡献，并分配两名护士 审核小组。 三位医师参与近期发表稿件 以及向 ASCO 会议提交的摘要。 我们打算增加这个 活动。 PI积极参与了多次NCI实地考察 和同行评审委员会。 我们的机构有一个特殊计划来促进和监督应计 少数族裔参加 NSABP 试验。 我们有一个独特的组织 基于学术界的 NSABP 试验的累积和执行 联盟（社区校园）和 PI 承担所有责任 与团体努力相关的活动。