HIPPOCAMPAL INTERNEURON SUBTYPES

海马中间神经元亚型

• 批准号: 2646586
• 负责人: Douglas Arthur Nitz
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2646586
• 关键词: Rodentias; brain electrical activity; cell population study; hippocampus; interneurons; psychophysiology; voltage /patch clamp

Current efforts at understanding the functioning of the hippocampus in, specifically, spatial information processing, and, in general, memory and learning are weakened by an incomplete knowledge of the role of hippocampal inhibitory interneurons. While a significant diversity of interneuron subtypes has been demonstrated anatomically and electrophysiologically (with the use of in vitro and anesthetized preparations), very little work has been done to identify interneuron subtypes based on unit recordings in behaving animals. Characterization of interneuron subtypes will aid in the understanding of the normal function of the hippocampus and will form a basis for identifying potential disorders of hippocampal interneurons thought to accompany aging and epilepsy. This project was initially designed to generate a basis for interneuron classification in freely behaving animals by combining behavioral paradigms known to modulate interneuron firing properties with pharmacological manipulation of subcortical afferents known to innervate the hippocampal interneuron population. In addition to progress made concerning the main goals of the project, the experiments have generated an important, but unexpected, finding concerning the roles of the dentate gyrus and CA1 hippocampal areas in spatial information processing. Some time has been devoted to handling this data properly. Thus, the present proposal seeks continuation of the original project.

目前努力了解海马体的功能， 具体来说，空间信息处理，以及一般来说，记忆 对角色的不完全了解会削弱学习能力 海马抑制性中间神经元。 虽然存在显着的多样性 中间神经元亚型已在解剖学上得到证实 电生理学（使用体外和麻醉 准备），很少有工作来识别中间神经元 基于行为动物的单位记录的亚型。 表征 中间神经元亚型的研究将有助于理解正常的 海马体的功能，并将形成识别的基础 被认为伴随的海马中间神经元的潜在疾病 衰老和癫痫。该项目最初旨在生成 自由行为动物的中间神经元分类的基础 结合已知的调节中间神经元放电的行为范式 皮层下传入的药理操作特性 已知可以支配海马中间神经元群。 此外 为了实现该项目的主要目标， 实验产生了一个重要但意想不到的发现 关于齿状回和 CA1 海马区的作用 空间信息处理。 花了一些时间来处理 这个数据正确。 因此，本提案寻求继续 原来的项目。