HUMAN GENETICS: DNA SEQ, MOLEC GEN, POSIT MAPPING, KELOIDS, HYPERTEN, ALZ

人类遗传学：DNA SEQ、MOLEC GEN、POSIT MAPPING、疤痕疙瘩、HYPERTEN、ALZ

• 批准号: 6121453
• 负责人: MANUEL SEVERO VALENZUELA
• 金额: $ 10.49万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121453
• 关键词: African American; Invertebrata; aging; biological products; biotechnology; building /facility design /renovation; genetics; genome; hematology; human tissue; minority institution research support; structural biology

These are two specific aims of the research that has been supported by RCMI funds. The first is an elucidation of the structure and function of repetitive DNA with special attention on heterochromatin. Heterochromatin has generally been referred to as inert DNA, but actually plays a critical role in chromo- some behavior during meiosis and mitosis, making it an essential part of the genome. The second aim is to identify the genetic basis of two inherited diseases, hypertension and keloids, that have a higher incidence in populations of African descent than in Caucasian populations. These diseases are part of a class of disorders that are more common in African-Americans and other populations of African decent called fibroproliferative diseases.

这是该研究的两个具体目标 由 RCMI 基金支持。 首先是结构的阐明 和重复DNA的功能，特别关注 异染色质。 异染色质通常被称为 惰性 DNA，但实际上在染色体行为中起着关键作用 在减数分裂和有丝分裂期间，使其成为基因组的重要组成部分。 第二个目标是确定两种遗传的遗传基础 高血压、疤痕疙瘩等疾病的发病率较高 非洲裔人口多于白人人口。 这些 疾病是一类更常见的疾病的一部分 非裔美国人和其他非洲裔人口被称为 纤维增生性疾病。