A6: HUMAN GENETICS: DNA SEQ, MOLEC GEN, POSIT MAPPING, KELOIDS, HYPERTEN, ALZ

A6：人类遗传学：DNA SEQ、MOLEC GEN、POSIT MMAPING、疤痕疙瘩、HYPERTEN、ALZ

• 批准号: 6205925
• 负责人: MANUEL SEVERO VALENZUELA
• 金额: $ 5.28万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205925
• 关键词: Invertebrata; inborn metabolism disorder

These are two specific aims of the research that has been supported by RCMI funds. The first is an elucidation of the structure and function of repetitive DNA with special attention on heterochromatin. Heterochromatin has generally been referred to as inert DNA, but actually plays a critical role in chromo- some behavior during meiosis and mitosis, making it an essential part of the genome. The second aim is to identify the genetic basis of two inherited diseases, hypertension and keloids, that have a higher incidence in populations of African descent than in Caucasian populations. These diseases are part of a class of disorders that are more common in African-Americans and other populations of African decent called fibroproliferative diseases.

这是研究的两个具体目的 由RCMI资金支持。 首先是阐明结构 重复DNA的功能，并特别注意 异染色质。 异染色质通常被称为 惰性DNA，但实际上在某些行为中起着至关重要的作用 在减数分裂和有丝分裂期间，使其成为基因组的重要组成部分。 第二个目的是确定两个继承的遗传基础 疾病，高血压和乳突，其发病率更高 非洲血统的种群比白人人群。 这些 疾病是一系列疾病的一部分，这些疾病在 非洲裔美国人和其他非洲人口称为 纤维增生性疾病。