COOPERATIVE HUMAN TISSUE NETWORK--PEDIATRIC

人体组织合作网络--儿科

• 批准号: 2875680
• 负责人: STEPHEN J QUALMAN
• 金额: $ 1.19万
• 依托单位: CHILDREN'S HOSPITAL (COLUMBUS)
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2875680
• 关键词: COOPERATIVE; HUMAN; TISSUE; NETWORK; PEDIATRIC

Significant therapeutic inroads have been made in pediatric and gynecologic cancers, but much remains to be discerned about the biology of these malignancies to be applied to their detection, diagnosis and treatment. The goal of the CHTN Pediatric/Gynecologic Division is to provide high quality research tissue specimens to support biomedical research involving pediatric and gynecologic malignancies. Historically, the Division's efforts have centered around pediatric and ovarian cancer with efforts now made to expand to include other important gynecologic (cervical, endometrial) cancers utilizing both snap-frozen and paraffin- embedded tissues. The Division has also expanded its reliance on focused cancer procurement through cooperative groups to include not only the Childrens Cancer Group and gynecologic Oncology Group, but also the Intergroup Rhabdomyosarcoma Study and National Wilms' Tumor Study. A focused effort to identify and track "liquid tumors" or the pediatric leukemias to make them widely available to investigators is also planned. Furthermore with the emphasis on molecular genetic research in pediatric/gynecologic cancer, procurement of associated host normal somatic tissues, metastatic tumor, blood and sera as well as familial blood for comparative nucleic acid studies is emphasized. These purposes are achieved through the usage of a dual chambered (ambient and deep frozen) Kit which is used in all studies. The Kit is recyclable and has been successfully piloted in 1994. Success of this CHTN Division has been measured by the publication of more than 70 manuscripts in various well-regarded clinical or basic research journals over the last grant cycle. Although uniquely positioned to procure pediatric and gynecologic malignancies for research purposes on a national basis, the CHTN Pediatric/Gynecologic Division effectively integrates with its adult counterparts in the CHTN in yearly operational planning, cross-referencing of investigator needs, a common computer network and in the common goal of procuring high quality tissues for scientifically sound biomedical research.

在小儿和 妇科癌症，但关于生物学的生物学还有很多差点 这些恶性肿瘤适用于它们的检测，诊断和 治疗。 CHTN儿科/妇科学的目标是 提供高质量的研究组织标本以支持生物医学 涉及儿科和妇科恶性肿瘤的研究。 从历史上看 该部门的努力集中在小儿和卵巢癌上 随着现在的努力扩展以包括其他重要的妇科 （宫颈，子宫内膜）使用snap冻结和石蜡的癌症 嵌入组织。 该部门还扩大了对重点的依赖 通过合作群体采购癌症，不仅包括 儿童癌症组和妇科肿瘤学组，也是 组间横纹肌肉瘤研究和国家威尔姆斯的肿瘤研究。 一个 集中精力识别和跟踪“液体肿瘤”或小儿 还计划了为调查人员广泛使用的白血病。 此外，重点是分子遗传研究 小儿/妇科癌，相关宿主正常的采购 体细胞组织，转移性肿瘤，血液和血清以及家族性 强调了用于比较核酸研究的血液。 这些目的 通过使用双腔室（环境和深度）来实现 冷冻）套件，用于所有研究。 该套件可回收，具有 在1994年成功驾驶。 该CHTN部门的成功已通过更多 在各种备受推崇的临床或基础研究中，超过70本手稿 在上一个赠款周期中的期刊。 虽然独特地定位 为研究目的采购小儿和妇科恶性肿瘤 国家基础，有效的CHTN小儿/妇科司有效 与其成人同行集成在年度运营中的CHTN 计划，调查员需求的交叉引用，一台普通计算机 网络和采购高质量组织的共同目标 科学的生物医学研究。