EICOSANOIC ACIDS IN TRYPANOSOMA BRUCEI

布氏锥虫中的二十烷酸

• 批准号: 2681706
• 负责人: Lawrence Ruben
• 金额: $ 19.83万
• 依托单位: SOUTHERN METHODIST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2681706
• 关键词: Trypanosoma brucei rhodesiense; biological signal transduction; calcium ion; cell death; eicosanoid metabolism; eicosanoids; endoplasmic reticulum; enzyme activity; fatty acid biosynthesis; laboratory mouse; life cycle; molecular cloning; phospholipase A2; protein purification; protein sequence

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal is based on the hypothesis that African trypanosomes utilize a variety of signaling pathways to coordinate life cycle events. During the course of studies on the control of Ca+ currents in T. brucei, they discoved key components of an eicosanoic acid pathway. The present proposal will examine how trypanosomes regulate Ca+/eicosanoic acid signals.

描述（改编自申请人的摘要）：该提案基于 假设非洲锥虫利用多种信号传导 协调生命周期事件的途径。 在学习期间 通过控制 T. brucei 中的 Ca+ 电流，他们发现了 二十烷酸途径。 本提案将研究锥虫如何 调节 Ca+/二十烷酸信号。