BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS

前脑控制血压

• 批准号: 2771247
• 负责人: SUSAN M BARMAN
• 金额: $ 15.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2771247
• 关键词: brain electrical activity; brain mapping; brain stem; cardiovascular function; catecholamines; cats; electrophysiology; interneurons; neural information processing; neuroanatomy; neurogenic hypertension; prosencephalon; serotonin; sympathetic nervous system

DESCRIPTION: (adapted from applicant's abstract) The long-range goal of this research is to characterize the CNS pathways that control basal sympathetic nerve discharge (SND) and cardiovascular function. Since 1990, the PI has studied the control of the 10-Hz rhythm that is the predominant feature of SND in decerebrate or urethane- anesthetized cats. This rhythm is highly coherent in nerves controlling a variety of cardiovascular target organs and may be a prerequisite for inducing the complex patterns of spinal sympathetic outflow that accompany some behavioral states. Studies during the current funding period are the first to identify specific CNS sites that regulate this activity. Data from antidromic activation experiments have indicated reciprocal connections between some of these areas and pharmacologic studies have suggested neurotransmitter systems that are important in the control of the 10 hz rhythm in SND. In the proposed 5-yr research plan, state-of-the-art electrophysiologic and analytic techniques will be combined with microiontophoresis and microinjection of drugs to address 4 Specific aims: (1) To test the hypothesis that pontine neurons in the A5, A6 and parabrachial/Kolliker- Fuse complex are involved in the control of the 10 Hz rhythm, (2) To identify the interconnections and signs (excitation or inhibition) of synaptic connections among brainstem neurons with activity correlated to the 10 Hz rhythm in SND, (3) To test the hypothesis that the 10 Hz rhythm is generated by a distributed network of brainstem neurons, and (4) to identify the central sites where serotonergic and catecholaminergic neurons act to affect the balance between the 10 Hz rhythm and the irregular 2-6 Hz oscillations in SND. These studies will enhance our understanding of the central circuitry responsible for generating and controlling the 10 Hz rhythm in resting SND.

描述：（改编自申请人的摘要）远程目标 这项研究的特征是控制控制的CNS途径 基础交感神经排出（SND）和心血管功能。 自1990年以来，PI研究了10 Hz节奏的控制 是SND在杂交或氨基甲烷中的主要特征 麻醉猫。这种节奏在神经中高度连贯 控制各种心血管靶器官，可能是 诱导脊柱同情的复杂模式的先决条件 伴随某些行为状态的流出。在 当前的资金期是第一个识别特定中枢神经系统的资金 调节此活动的站点。来自抗体激活的数据 实验表明其中一些之间的相互联系 这些领域和药理学研究表明神经递质 对于控制SND中10 Hz节奏很重要的系统。 在拟议的5年研究计划中，最先进的电生理学 和分析技术将与微离子噬菌体结合 和微注射以解决4个特定目的：（1）测试 假设A5，A6和parabrachial/kolliker- 保险丝复合物与10 Hz节奏的控制有关，（2） 识别互连和符号（激发或抑制） 与活动的脑干神经元之间的突触连接 与SND中的10 Hz节奏相关，（3）检验了以下假设。 10 Hz节奏是由脑干分布式网络产生的 神经元和（4）确定血清素能和 儿茶酚胺能神经元可影响10 Hz之间的平衡 SND中的节奏和不规则的2-6 Hz振荡。这些研究 将增强我们对中央电路负责的理解 用于生成和控制静止SND中的10 Hz节奏。