HYPERGLYCEMIA EFFECT ON FOREBRAIN & BRAINSTEM ACTIVATION FROM RECTAL DISTENTION

高血糖对前脑的影响

• 批准号: 6297159
• 负责人: WILLIAM D CHEY
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297159
• 关键词: afferent nerve; anorectal disorder; brain electrical activity; brain mapping; brain stem; clinical research; gastrointestinal sign /symptom; human subject; hyperglycemia; perception; positron emission tomography; prosencephalon

The pathophysiology of constipation in the setting of longstanding diabetes mellitus is not well understood. We have found that acute hyperglycemia blunts the perception of rectal distention in healthy volunteers without altering rectal compliance or peripheral afferent neural function between the rectum and cortical structures. In the current study, we plan to use PET scanning to localize the forebrain and brainstem structures active during the perception of rectal stimulation. We will further evaluate the effect of acute hyperglycemia on the activation of these structures. The causes of constipation in patients with diabetes mellitus are poorly understood. We have found that elevated blood sugar levels affects the sensation of a balloon inflated in the rectum. We plan to use positron emission tomography to determine which parts of the brain are activated in response to inflating a balloon in the rectum. In addition, we will study whether activation of different parts of the brain is altered after artificially raising a person's blood sugar level.

在长期糖尿病的情况下，便秘的病理生理尚不清楚。我们发现，急性高血糖在健康志愿者中对直肠扩张的感知，而不会改变直肠和皮质结构之间的直肠依从性或外周神经功能。在当前的研究中，我们计划在直肠刺激感知期间使用PET扫描来定位活跃的前脑和脑干结构。我们将进一步评估急性高血糖对这些结构激活的影响。糖尿病患者的便秘原因知之甚少。 我们发现，血糖水平升高会影响直肠膨胀的气球的感觉。我们计划使用正电子发射断层扫描来确定响应直肠中的气球膨胀的大脑的哪些部分。 此外，我们将研究在人为地提高人的血糖水平后，大脑不同部位的激活是否会改变。