ENERGETIC ADAPTATION TO THE MENOPAUSE TRANSITION

精力充沛地适应更年期过渡

• 批准号: 2769403
• 负责人: ERIC T. POEHLMAN
• 金额: $ 26.4万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769403
• 关键词: adipose tissue; aging; bioenergetics; body composition; body physical activity; calorimetry; cardiovascular disorder; clinical chemistry; clinical research; computed axial tomography; disease /disorder proneness /risk; female; glucose clamp technique; human middle age (35-64); human subject; insulin sensitivity /resistance; interview; longitudinal human study; mass spectrometry; menopause; nutrient intake activity; nutrition related tag; questionnaires; radioimmunoassay; urinalysis; women's health

Loss of ovarian function accelerates the risk of cardiovascular and metabolic disease, and heralds the onset of changes that can have far-reaching consequences on women's future health. We will examine the impact of the menopause transition on several metabolic and cardiovascular risk factors associated with declining health status in women. Our overall hypothesis is that women who experience a natural menopause transition will show - accelerated decline in daily energy expenditure, increase in total and Intra-abdominal body fat and decline in insulin sensitivity. In this 5-year longitudinal study, we will recruit 57 premenopausal women and examine their natural history as they traverse the menopause. Changes in energy expenditure, body composition, body fat distribution and insulin sensitivity will be measured annually (a total of five exams) to examine the time course of menopause and age-related changes in outcome variables. Our First Aim will examine the effects of the menopause transition on total daily energy expenditure, body fat distribution and insulin sensitivity. We will use: 1) doubly labeled water and indirect calorimetry to measure changes in total daily energy expenditure, resting metabolic rate, thermic effect of a meal and physical activity; 2) computerized tomography to assess changes in intra-abdominal body fat and 3) euglycemic clamps to measure insulin sensitivity. Our Second Aim is to develop and cross-validate new models to predict daily energy requirements, as derived from biological markers of total daily energy expenditure in pre- and postmenopausal women and to compare them to current daily energy intake recommendations. Current recommendations for daily energy needs are based on out- dated food intake data and have not considered the influence of menopause status, body composition and physical activity as determinants of daily energy needs. These limitations have led to the suggestion that prescription of daily energy requirements should be based on the measurement of total daily energy expenditure. Analyses of these data will characterize the biological and metabolic sequelae of changes in energy metabolism, body fat distribution and insulin sensitivity in women as they traverse the menopause. Furthermore, we will offer new guidelines to predict energy requirements during the menopause transition.

卵巢功能的损失加速了心血管的风险 代谢性疾病，并预示着可能具有的变化 对妇女未来健康的影响深远。我们将检查 更年期过渡对几种代谢和 与健康状况下降有关的心血管危险因素 在女性中。我们的总体假设是经历了 自然更年期过渡将显示 - 加速下降 每日能量消耗，腹腔内和腹腔内增加 体内脂肪和胰岛素敏感性下降。在这个五年中 纵向研究，我们将招募57名绝经前妇女 在穿越更年期时，检查他们的自然历史。 能量消耗，身体成分，身体脂肪的变化 每年将测量分布和胰岛素敏感性（a 总共五项考试）检查更年期和 结局变量与年龄有关的变化。我们的第一个目标 检查更年期过渡对每日总数的影响 能量消耗，体内脂肪分布和胰岛素敏感性。 我们将使用：1）双重标记的水和间接量热法 衡量每日能源总消耗的变化，休息 代谢率，进餐的热效应和体育锻炼； 2） 计算机断层扫描以评估腹腔内身体的变化 脂肪和3）测量胰岛素敏感性的电远离夹具。我们的 第二个目的是开发和交叉验证新模型以预测 每日能源需求，从生物标记中得出 绝经前和绝经后妇女的每日能量支出 将它们与当前的每日能量摄入建议进行比较。 目前对日常能源需求的建议是基于户外的 过时的食物摄入数据，没有考虑 更年期状态，身体成分和体育锻炼 日常能源需求的决定因素。这些限制导致了 每日能源需求的处方 应基于对每日总能量的测量 支出。这些数据的分析将表征 能量代谢变化的生物和代谢后遗症， 女性的体内脂肪分布和胰岛素敏感性 穿越更年期。此外，我们将提供新的准则 预测更年期过渡期间的能源需求。