CONFERENCE ON NUCLEAR RECEPTOR GENE FAMILY

核受体基因家族会议

• 批准号: 2555795
• 负责人: KATHRYN B HORWITZ
• 金额: $ 2.66万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-21 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2555795
• 关键词: genetic regulatory element; hormone receptor; meeting /conference /symposium; retinoid binding proteins; steroid hormone receptor; transcription factor; travel; vitamin D receptors

The steroid, thyroid, retinoic acid PPAR and vitamin D receptors, plus a growing number of orphan receptors are members of a superfamily of nuclear proteins that regulate transcription. These receptors control, among other things, developmental processes, tissue-specific differentiation, the growth and death of normal and malignant cells, reproductive behavior and metabolic activity. They act directly by binding to the hormone response elements of target promoters, or indirectly, by mechanisms that include interactions with transcriptional coregulators, or cross-talk with other signaling pathways. Among the problems facing this field are the mechanisms of tissue-specific regulation; cell-cycling and cancer; interactions with coregulatory factors; transcriptional integration of cell surface/nuclear receptor signals; the regulatory role of chromatin; post-translational modifications of receptors and isoform-specific actions; mechanisms of antagonists; receptor and domain structure; the function of orphan receptors. The intent of this meeting is to bring together leading experts in this diverse field, joined by younger investigators and trainees entering the field. The program includes state-of-the-art plenary lectures plus poster sessions. Selected abstracts authored by junior attendees will be chosen prior to the conference date and scheduled for 10-minute oral presentations. Our goal is two fold: First, to nurture and extend the intellectual interactions fostered by previous Keystone Symposia conferences on this receptor family. Second, to create a venue at which students and fellows can orally present their data to the fully assembled group.

类固醇，甲状腺，视黄酸PPAR和维生素D受体，加上 越来越多的孤儿受体是 调节转录的核蛋白。这些受体控制， 除其他事项外，发育过程，特定于组织 分化，正常和恶性细胞的生长和死亡， 生殖行为和代谢活性。 他们直接采取行动 与靶启动子的激素反应元件的结合，或 间接通过包括与转录相互作用的机制 核心节，或与其他信号通路进行串扰。 在 该领域面临的问题是组织特异性的机制 规定;细胞循环和癌症；与核调节的相互作用 因素；细胞表面/核受体的转录整合 信号；染色质的调节作用；翻译后 受体和同工型特异性作用的修饰；机制 对手；受体和域结构；孤儿的功能 受体。 这次会议的目的是将领先的专家汇集在一起 各种领域，与年轻的调查员和学员一起进入 场地。 该计划包括最先进的全体讲座以及 海报会议。 由初级与会者撰写的精选摘要将 在会议日期之前选择，并计划进行10分钟的口服 演讲。我们的目标是两个折：首先，培养和扩展 以前的Keystone研讨会培养的智力互动 关于这个受体家族的会议。 第二，创建一个场所 学生和研究员可以口头向完全介绍他们的数据 组装组。