ENVIRONMENTAL DETERMINANTS OF IXODES DAMMINI EXPANSION

IXODES DAMMINI 扩张的环境决定因素

基本信息

批准号：
2672232
负责人：
MARK L WILSON
金额：
$ 8.44万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-05-01 至 2001-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2672232
关键词：
Ixodes Lyme disease animal ecology animal population study computer simulation disease vectors environment field study geographic site hamsters host organism interaction insect control laboratory rabbit mathematical model model design /development statistics /biometry

项目摘要

Lyme disease has recently emerged as the most prevalent vector-borne illness in the United States, and evidence suggests that its distribution is continuing to expand. Ixodes dammini, the sole vector of importance in northeastern U.S., is widely but patchily distributed in parts of the region. During the past 2 decades, the range of I. dammini and Lyme disease has spread to encompass much of the coastal northeast; enigmatically, movement inland has been slow and spatially variable. Neither low frequency of new tick introductions nor unavailability of appropriate vertebrate hosts can adequately explain why this vector has not more rapidly invaded certain regions. We propose to use laboratory and field experiments, and a novel technique for modeling and analysis of spatial relations termed Geographical Information Systems (GIS), to determine how non-host, environmental factors influence the survival and limit the range of I. dammini in the northeastern U.S. Specifically, we shall determine I. dammini abundances throughout the states of Connecticut and Massachusetts by sampling ticks on hunter-killed white-tailed deer, and calculating variation in tick abundances over the entire region of both states. These results will be integrated with the spatial distributions of climatic, vegetation, soil, altitude and other environmental data from the same areas. Using GIS, we will analyze the environmental determinants of this tick's macrogeographic distribution, and model the rate and direction of its spread. Other laboratory and field studies will examine the effects of various microclimatic conditions on the off-host survival of coastal northeastern and northern mid-western populations of I. dammini. Microgeographic variation in I. dammini abundance will be evaluated in relation to microclimate and vegetation, while controlling for habitat use by radio-collared deer. The long-term impact of habitat manipulation on I. dammini abundance will be studied by various experiments that may be useful in local tick control efforts. Our ultimate goal is to determine the environmental conditions that presently limit the distribution of I. dammini, where and at what rate new infestations might be anticipated, and how the impact on public health resulting from the expanding range of this Lyme disease vector may be lessened.

莱姆病最近成为最普遍的载体传播美国的疾病，证据表明其分布正在继续扩展。 ixodes dammini，唯一重要的向量美国东北部，广泛但斑点分布在地区。在过去的20年中，I。Dammini和Lyme的范围疾病已经扩散到涵盖东北沿海的大部分地区；神秘地，内陆运动速度缓慢且空间变化。既不是新的壁虱介绍的低频适当的脊椎动物宿主可以充分解释为什么该向量有没有更迅速地入侵某些地区。我们建议使用实验室和现场实验，以及一种用于建模和分析的新技术空间关系称为地理信息系统（GIS），确定非宿主，环境因素如何影响生存和限制美国东北部的I. Dammini的范围具体而言，我们将确定I. Dammini的丰度康涅狄格州和马萨诸塞州通过在猎人杀死的白尾鹿，并计算出与两个州的整个地区。这些结果将与气候，植被，土壤，海拔和其他的空间分布来自同一地区的环境数据。使用GIS，我们将分析环境决定因素的宏观地理分布，并建模其传播的速率和方向。其他实验室和现场研究将检查各种微气候条件的影响在中西部沿海和北部沿海的户外生存中 I. Dammini的种群。 I. Dammini的微地理变化将与微气候和植被有关的丰度评估在控制无线电鹿使用栖息地的同时。长期栖息地操纵对I. Dammini丰度的影响将由各种实验可能在本地tick控制工作中有用。我们的最终目标是确定环境条件目前限制I. Dammini的分布可能会预期侵扰，以及如何对公共卫生的影响由于该莱姆病载体的扩展范围可能是减少。