ATTENTION DISORDERS AS ASSESSED BY EVENT RELATED BRAIN POTENTIALS

通过事件相关的大脑潜能评估注意力障碍

• 批准号: 2578678
• 负责人: Allan F. Mirsky
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2578678
• 关键词: Tourette's syndrome; attention; attention deficit disorder; behavior test; brain electrical activity; brain injury; child (0-11); clinical research; cognition disorders; dyslexia; eating disorders; electrophysiology; epilepsy; evoked potentials; human subject; magnetic resonance imaging; mental disorder diagnosis; mental disorders; nervous system disorder; neural information processing; neurochemistry; pathologic process; psychophysiology; schizophrenia; seasonal affective disorder

The aim of this project is to investigate the roles of brain event-related potentials, attention, and information processing and their interrelationships in the etiology, pathology, and prognosis of psychiatric and neurological disorders. Major emphasis is on the diagnostic specificity of disorders of attention and cognition and the identification of the specific aspects or stages of information processing underlying observed decrements in performance. Concurrently recorded brain event- related potentials and performance on cognitive tasks are used to differentiate patterns of dysfunctions in attentive mechanisms in subjects with diagnoses of schizophrenia, seizures, seasonal affective disorder, eating disorders, dyslexia, closed head injury, attention deficit hyperactivity disorder, and Tourette's disorder. A related objective of this project is to differentiate state versus trait attributes of these disorders to increase understanding of their etiologies. Brain event- related potentials are also used to investigate the role of altered neurochemical mechanisms by comparing drug-induced electrophysiological and behavioral effects with those seen in the various disorders. Correlations between brain event-related potentials and neuroimaging (magnetic resonance imaging) data are used to study the relationship between indices of information processing and the volume of brain regions implicated in the pathophysiology of schizophrenia. Psychological correlates are investigated by relating the data to extensive neuropsychological, psychiatric, and personality measures as well as to performance on behavioral tasks.

该项目的目的是研究与大脑事件相关的作用 潜力，注意力和信息处理及其 精神病学，病理学和预后的相互关系 和神经系统疾病。 重点是诊断 注意力和认知和认同的特异性 信息处理的特定方面或阶段 观察到的性能下降。 同时记录大脑事件 - 相关的潜力和认知任务的表现用于 区分受试者专注机制中功能障碍的模式 诊断精神分裂症，癫痫发作，季节性情感障碍， 饮食失调，阅读障碍，头部受伤，注意力不足 多动症和图雷特障碍。 一个相关目标的 该项目是为了区分状态与特征属性 疾病以增加对其病因的理解。 大脑事件 - 相关电位还用于研究改变的作用 通过比较药物诱导的电生理学和神经化学机制 在各种疾病中看到的行为影响。 相关性 在大脑事件相关电位和神经影像之间（磁共振）之间 成像）数据用于研究指数 信息处理和与大脑区域的数量有关 精神分裂症的病理生理。 心理相关性是 通过将数据与广泛的神经心理学联系起来进行调查， 精神病和性格措施以及表现 行为任务。