GENETICS OF KELOIDS

瘢痕疙瘩的遗传学

• 批准号: 2517413
• 负责人: KAREN D DAVIS
• 金额: $ 2.06万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-08 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2517413
• 关键词: clinical research; family genetics; genetic markers; human data; human genetic material tag; human subject; keloid skin disorder; linkage mapping; polymerase chain reaction

Keloids are benign fibrous growths caused by abnormal wound healing occurring in some individuals and their relatives. This condition is common in individuals of African and Asian descent. The precise molecular and biochemical dysfunctions that lead to keloid formation remains unknown. However, there appears to be a genetic predisposition. Given this possible genetic predisposition to keloids, I propose a positional cloning strategy to identify the genes responsible for keloids. l) Using segregation analysis in affected families, the mode of inheritance will be analyzed 2) Linkage analysis will also be used to identify the chromosomal location of the predisposing gene for the purpose of ultimately cloning and characterizing the genetic lesion. Based on research conducted at Meharry Medical College on keloids, members of the jun/fos family of transcription factors have been chosen as candidate genes for the linkage analysis. The results of this proposal should help us to understand the mechanism of wound healing in keloids.

疤痕疙瘩是由伤口愈合异常引起的良性纤维生长 发生在某些个人及其亲属中。 这个条件是 常见于非洲和亚洲血统的人。 精确的 导致疤痕疙瘩形成的分子和生化功能障碍 仍然未知。然而，似乎存在遗传倾向。 鉴于疤痕疙瘩可能存在遗传倾向，我建议 定位克隆策略，以确定负责的基因 疤痕疙瘩。 l) 通过对受影响家庭进行隔离分析， 继承将被分析 2) 连锁分析也将被用来 确定易感基因的染色体位置 最终克隆和表征遗传损伤的目的。 根据梅哈里医学院对疤痕疙瘩进行的研究， 已选择转录因子 jun/fos 家族的成员 作为连锁分析的候选基因。本提案的结果 应该有助于我们了解疤痕疙瘩伤口愈合的机制。