GABA RECEPTORS IN ETHANOL PLACE PREFERENCE AND AVERSION

乙醇中 GABA 受体的偏好和厌恶

• 批准号: 2410684
• 负责人: JULIA ANN CHESTER
• 金额: $ 1.99万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2410684
• 关键词: GABA receptor; association learning; avoidance behavior; behavioral /social science research tag; bicuculline; conditioning; ethanol; gamma aminobutyrate; inbreeding; laboratory mouse; motivation; neuropharmacology; preference; reinforcer

The broad, long-term goal of the proposed project is to investigate a role for the GABA neurotransmitter system in modulating the rewarding and aversive properties of ethanol. The proposed studies will utilize the place conditioning paradigm to examine the acquisition of conditioned place preference (CPP) and conditioned place aversion (CPA) in DBA/2J mice. The place conditioning procedure provides a useful model to study the learned association between environmental stimuli and a drug's rewarding and aversive effects, and allows for the investigation of specific neural pathways involved in the acquisition of place conditioning. Although the GABA system has been implicated in mediating many of ethanol's behavioral effects, it has not yet been investigated as a possible modulator of ethanol-induced CPP or CPA. The specific aims of this project are to test various doses of pharmacological antagonists selective for GABAA and GABAB receptor subtypes in the acquisition of ethanol-induced CPP and CPA. These studies will help elucidate the role of GABA in modulating the acquisition of conditioned responses to ethanol's neuropharmacological effects. Overall, the information gained from this project will contribute to an understanding of the neurochemical substrates underlying the motivational effects of ethanol. Studies such as these are important in order to develop appropriate clinical treatments for ethanol-seeking and addictive behavior in humans.

拟议项目的广泛长期目标是调查角色 为GABA神经递质系统调节奖励和 乙醇的厌恶特性。 拟议的研究将利用 放置条件范式以检查条件的习得 放置偏好（CPP）和条件的位置厌恶（CPA）在DBA/2J中 老鼠。 该地点调节程序为研究提供了有用的模型 环境刺激与药物之间的学识渊博的关联 奖励和厌恶效果，并允许调查 涉及地点涉及的特定神经途径 调理。 尽管GABA系统与中介有关 许多乙醇的行为影响，尚未被调查为 乙醇诱导的CPP或CPA的可能调节剂。 具体目的 该项目是为了测试各种剂量的药理学拮抗剂 在获取中的GABAA和GABAB受体亚型的选择性 乙醇引起的CPP和CPA。 这些研究将有助于阐明角色 GABA调节对条件响应的收购 乙醇的神经药物作用。 总体而言，获得的信息 从这个项目中将有助于理解 神经化学底物是乙醇的动机作用的基础。 这样的研究对于开发适当的研究很重要 人类寻求乙醇和成瘾行为的临床治疗方法。