MODEL BASED APPROACH TO ADDUCTOR SPASMODIC DYSPHONIA

基于模型的内收肌痉挛性发音障碍方法

• 批准号: 2430096
• 负责人: VICKI L HAMMEN
• 金额: $ 3.69万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430096
• 关键词: antispasmodic agents; botulinum toxins; clinical research; disease /disorder model; human subject; human therapy evaluation; larynx; longitudinal human study; neuromuscular disorder chemotherapy; pulmonary respiration; questionnaires; speech disorders; voice

Spasmodic dysphonia (SD) is a disturbing disorder of laryngeal motor control, that although considered rare, has a profound impact on the communicative, social and vocational abilities of the individual. The use of botulinum toxin (BOTOX) injections as a treatment for SD has been supported by a number of researchers. The published studies in this area to date have focused on changes in acoustic and perceptual characteristics following BOTOX injections. Yet little attention has been focused on the broader impact of this form of treatment on the communicative abilities of these patients. To adequately address the effect of this disorder and its most popular treatment approach on the individual, a multi-dimensional approach to assessing its effectiveness in needed. One such approach is a three-tier model of chronic disease in which impairment, disability and handicap are assessed. To date, this, or any other model-based approach, has been applied to voice disorders. One of the goals of Healthy People 2000 is to reduce the proportion of people who experience a limitation in major activity due to a chronic disability (US Dept of HHS/PHS, 1990). Spasmodic dysphonia qualifies as a chronic disability so it is important to begin to utilize more comprehensive ways of characterizing this disorder and its impact on an individual. Therefore, exploration of the use of a model of chronic disease is timely and warranted. This research proposal will address the following question: What is the impact of spasmodic dysphonia and BOTOX treatment on the model of chronic disease? The specific aims of this project are: 1) to identify aerodynamic an respiratory measures that will reliably reflect the impairment related to SD, 2) to explore a measure of perceived vocal effort level as an indicator of functional limitation, 3) to refine a questionnaire designed to measure the perceived functional limitation of SD, 4) to identify measurement tools which may adequately track the outcome of intervention. Ten subjects with idiopathic spasmodic dysphonia will participate in several experimental protocols designed to characterize the impairment, functional limitation and disability associated with spasmodic dysphonia and the effect of BOTOX injections on these same indices. These same subjects will be followed longitudinally through a series of injections to determine the changes in the levels of the model that occur during treatment with BOTOX. It is expected that the information obtained from this investigation will suggest the relationships among the levels of a model of chronic disease.

痉挛性吞咽困难（SD）是喉部运动的干扰障碍 控制虽然被认为是罕见的，但对 个人的沟通，社会和职业能力。使用 肉毒杆菌毒素（肉毒杆菌毒素）注射作为SD的治疗 由许多研究人员的支持。该领域已发表的研究 迄今为止，集中于声学和知觉的变化 肉毒杆菌注射后的特征。然而几乎没有关注 专注于这种形式的治疗对 这些患者的沟通能力。充分解决 这种疾病的影响及其最受欢迎的治疗方法对 个人，一种评估其有效性的多维方法 在需要。一种这样的方法是一种三级模型的慢性疾病模型 评估哪些障碍，残疾和障碍。迄今为止， 或任何其他基于模型的方法已应用于语音障碍。 2000年健康人的目标之一是减少 由于慢性而遭受重大活动限制的人 残疾（HHS/PHS的美国部，1990年）。痉挛性吞咽困难有资格 慢性残疾，因此重要的是要开始使用更多 全面表征这种疾病及其对 个人。因此，探索慢性模型的使用 疾病是及时的，有保证的。 该研究建议将解决以下问题：什么是 痉挛性吞咽困难和肉毒杆菌治疗对慢性模型的影响 疾病？该项目的具体目的是：1）确定 空气动力学的呼吸措施将可靠地反映 与SD相关的障碍，2）探索一种感知的人声 努力水平作为功能限制的指标，3）完善 调查表旨在衡量感知的功能限制 SD，4）确定可以充分跟踪的测量工具 干预的结果。 十个特发性痉挛性烦躁不安的受试者将参加 旨在表征损害的几种实验方案， 与痉挛性吞咽困难相关的功能限制和残疾 肉毒杆菌毒素对这些相同指数的影响。这些一样 将通过一系列注射纵向遵循受试者 确定模型级别的变化 用肉毒杆菌毒素治疗。预计从 这项调查将表明 慢性病模型。