ORAL FINDINGS IN HIV INFECTION--DIFFERENT RISK GROUPS

HIV 感染的口腔检查结果——不同的风险群体

• 批准号: 2130608
• 负责人: IRA B LAMSTER
• 金额: $ 68.57万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-15 至 1996-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2130608
• 关键词: HIV infections; clinical trials; dental disorder; disease /disorder proneness /risk; human subject; longitudinal human study

Infection with the human immunodeficiency virus (HIV), and its terminal clinical stage, acquired immunodeficiency syndrome (AIDS), were first described in homosexual males. Subsequently, a second major risk group for HIV infection consisting of intravenous drug users (IVDU) was identified. Among the important clinical manifestations of HIV disease is the occurrence of unusual oral lesions. The frequency and distribution of these lesions were originally described in homosexual males with AIDS. Oral manifestations of HIV infection may be an early clinical sign of disease progression, but the significance of these lesions to other aspects of HIV disease have not been defined. Two broad questions concerning the oral manifestations of HIV infection can be posed: 1. What differences exist in the occurrence of oral manifestations of HIV disease if different risk groups and 2. What is the temporal relationship of development of HIV infection and its accompanying immunodeficiency to the development of both oral and systemic manifestations of the disease. This Program Project will address these issues by longitudinally studying patients being monitored by the HIV Center for Clinical and Behavioral Studies at the Psychiatric Institute/Columbia Presbyterian Medical Center. This Center studies a large cohort of homosexual males, male IVDU and female IVDU. All patients are either seronegative or seropositive, and have not progressed to clinical AIDS. These patients will receive an intraoral examination at each of their 6 month medical evaluations. Oral findings will be correlated with the immunologic and systemic changes that characterizes the development of HIV disease. In addition, this Program Project will comprehensively study host-microbial interaction as a function of developing immunodeficiency. Evaluating a subcohort of patients, the clinical progression of periodontal disease will be correlated with infection of the subgingival environment and the local and systemic host response. The Core section of this Program Project will provide the administrative logistical and statistical support to allow the studies to be performed.

人类免疫缺陷病毒（HIV）感染及其终末期 临床阶段，获得性免疫缺陷综合症（艾滋病），是第一个 描述于男性同性恋者。 随后，第二个主要风险群体 对于由静脉吸毒者 (IVDU) 组成的 HIV 感染者 确定。 HIV疾病的重要临床表现之一 是发生异常的口腔病变。 频率和 这些病变的分布最初是在同性恋中描述的 患有艾滋病的男性。 HIV 感染的口腔表现可能是早期症状 疾病进展的临床症状，但这些的意义 HIV 疾病其他方面的损害尚未确定。 两宽 有关艾滋病毒感染的口腔表现的问题可以 提出：1.口腔表现的发生存在哪些差异 2. 不同风险群体的 HIV 疾病的发生率是多少？ HIV感染及其伴随的发展关系 免疫缺陷对口腔和全身发育的影响 疾病的表现。 该计划项目将解决这些问题 通过纵向研究受艾滋病毒监测的患者来解决问题 精神病学临床和行为研究中心 研究所/哥伦比亚长老会医疗中心。 该中心研究 一大群同性恋男性、男性 IVDU 和女性 IVDU。 全部 患者要么是血清阴性，要么是血清阳性，并且没有进展 到临床艾滋病。这些患者将接受口内检查 在每次 6 个月的医疗评估中。 口头调查结果将 与特征性的免疫学和系统性变化相关 艾滋病毒疾病的发展。 此外，该计划项目将 全面研究宿主与微生物之间的相互作用 出现免疫缺陷。 评估患者亚组时， 牙周病的临床进展与以下因素相关： 龈下环境以及局部和全身宿主的感染 回复。 该计划项目的核心部分将提供 为研究提供行政后勤和统计支持 待执行。