ALTERED BRAIN METABOLISM INDUCED BY DIABETES IN MAN

人类糖尿病引起的大脑代谢改变

• 批准号: 2037473
• 负责人: PATRICK J. BOYLE
• 金额: $ 10.79万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2037473
• 关键词: artificial endocrine pancreas; blood brain barrier; blood flow measurement; blood glucose; brain metabolism; central nervous system; deuterium; diabetes mellitus; diabetes mellitus therapy; dietary supplements; drug receptors; epinephrine; glucose metabolism; hyperglycemia; hyperinsulinism; hypoglycemia; insulin; insulin dependent diabetes mellitus; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; nutrient intake activity; nutrition related tag; sulfonylurea

The candidate's immediate goal is to continue his transition toward a fully independent investigator status with emphasis of the field of brain metabolism in diabetic man. The overall goal of these studies is to provide a more through understanding of the critical role the brain plays in regulating systemic glucose metabolism in patients with diabetes. The central nervous system is almost completely dependent upon a constant supply of glucose from the circulation in order to function normally. Yet, brain tissues are able to make and store only a few minutes-worth of glucose for periods when the body's supply to the brain is interrupted (i.e., hypoglycemia). A major goal of the proposed investigations is to better define the role which the central nervous system plays in preventing and reacting to changes in systemic glucose concentration (either hyper- or hypoglycemia) in man. The relevance of these investigation is underscored by experience with the Diabetes Control and Complications Trial, which has discovered a greatly increased risk of severe hypoglycemia in patients attempting to fully normalize their glycemic control. If intensive insulin therapy is found to prevent complications of diabetes, then more effective treatment strategies will need to be defined in order to reduce the overall risk of hypoglycemia. Such a task would be greatly facilitated by a better understanding of changes in central nervous system glucose metabolism that may occur in association with the diabetic state. Other aspects of brain energy metabolism in the setting diabetes in man.will be examined including the direct roles that insulin and epinephrine may play in determining rates of brain glucose utilization. Finally, the contributing role that the brain may play in disposing of consumed glucose in health and in the diabetic state will be compared. The investigations described rely upon the direct measurement of brain glucose utilization in man by the cross-brain glucose balance technique originally developed by Kety and Schmidt. The technique is a highly reliable quantification of cerebral blood flow coupled with measurement of cross-brain glucose extraction.

候选人的近期目标是继续向 完全独立的研究者身份，重点关注脑领域 糖尿病人的新陈代谢。 这些研究的总体目标是 通过了解大脑所扮演的关键角色提供更多信息 调节糖尿病患者的全身葡萄糖代谢。 这 中枢神经系统几乎完全依赖于一个常数 从循环中供应葡萄糖才能正常运作。 然而，脑组织只能制造和储存几分钟的信息 当身体对大脑的供应中断时，需要补充葡萄糖 （即低血糖）。 拟议调查的一个主要目标是 更好地定义中枢神经系统在其中所起的作用 预防和应对全身葡萄糖浓度的变化 男性（高血糖或低血糖）。 这些内容的相关性 糖尿病控制方面的经验强调了调查的重要性 并发症试验，发现并发症的风险大大增加 试图使血糖完全正常化的患者出现严重低血糖 血糖控制。 如果发现强化胰岛素治疗可以预防 糖尿病并发症，那么更有效的治疗策略将 需要对其进行定义，以降低低血糖的总体风险。 如果更好地理解 中枢神经系统葡萄糖代谢的变化可能发生在 与糖尿病状态的关联。 大脑能量的其他方面 人类糖尿病背景下的新陈代谢将被检查，包括 胰岛素和肾上腺素在确定速率中可能发挥的直接作用 大脑葡萄糖利用。 最后， 大脑可能在健康和生活中处理消耗的葡萄糖方面发挥作用 将比较糖尿病状态。 所描述的调查依赖于 直接测量人类大脑葡萄糖的利用 跨脑葡萄糖平衡技术最初由 Kety 和 施密特。 该技术是一种高度可靠的大脑定量技术 血流量与跨脑葡萄糖提取的测量相结合。