CONTROLLED STUDY OF ANABOLIC STEROID USE IN WOMEN

女性使用合成代谢类固醇的对照研究

基本信息

批准号：
2377427
负责人：
HARRISON G POPE
金额：
$ 10.73万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-03-01 至 1998-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2377427
关键词：
adipose tissue androgen analog blood chemistry body physical characteristic clinical research dosage drug abuse drug detection drug withdrawal female human subject interview mental health epidemiology physical fitness psychological tests toxicology urinalysis women's health

项目摘要

A growing literature suggests that anabolic-androgenic steroids, drugs which promote gains in muscle mass and loss of body fat, are widely abused by Americans. Many studies have shown that in men, steroids can lead to both medical and psychiatric morbidity. For example, a recent study from this laboratory, comparing 88 steroid-using men with 68 matched controls, found a markedly increased prevalence of major mood syndromes in association with both steroid use and steroid withdrawal. However, very few studies have examined the nature and effects of steroid use in women, despite evidence that more than 100,000 American women have abused these drugs. The study proposed in this application seeks to duplicate in women the investigators' previous design, used in the study of men described above. In the proposed study, 30 steroid-using women and 30 non-using women will be recruited from gymnasiums in two metropolitan areas, using a recruitment process designed to minimize selection bias. Subjects will be interviewed, using an instrument refined from the investigators' pilot study, and will submit urine to be tested for both steroids and other drugs. They will also receive a physical examination, including caliper determinations of body fat, and have blood drawn for standard chemistry and hematology measures. Users and non-users will be compared on basic demographic variables, medical history, physical and laboratory findings, and incidence of psychiatric symptoms and syndromes during and in the absence of steroid exposure. Although the proposed study is naturalistic, and relies on retrospective reports by subjects, this method represents the only design capable of assessing the nature and effects of steroid abuse in women, since it is not ethically reasonable to examine these effects in the laboratory.

越来越多的文献表明合成代谢 - 源源于类固醇，药物促进肌肉质量和体内脂肪损失的收益广泛被美国人虐待。许多研究表明，在男性中，类固醇可以导致医学和精神病发病率。例如，最近来自该实验室的研究，比较88种类固醇的男性与68 匹配的控件，发现主要情绪的患病率显着增加综合征与类固醇使用和类固醇戒断相关。但是，很少有研究检查类固醇的性质和影响尽管有证据表明有100,000多名美国妇女有妇女的使用滥用了这些药物。本申请中提出的研究旨在重复女性研究人员的先前设计，用于上述男性研究。在拟议的研究中，将有30名使用类固醇的妇女和30位不使用的女性从两个都会区的体育馆招募，使用旨在最大程度地减少选择偏差的招聘过程。受试者会使用调查人员的飞行员的仪器进行采访研究，并将提交尿液进行类固醇和其他类固醇的测试毒品。他们还将接受体格检查，包括卡钳测定体内脂肪，并为标准化学抽血和血液学措施。用户和非用户将在基本上进行比较人口统计学变量，病史，物理和实验室发现，和精神症状和综合症的发生率和综合症缺乏类固醇暴露。尽管拟议的研究是自然主义的，并且依赖于回顾通过受试者的报告，此方法代表了唯一能够的设计评估女性类固醇滥用的性质和影响，因为它是在实验室中检查这些效果在道德上是不合理的。