PRIMARY VISCERAL AFFERENTS IN PAIN

疼痛时的原发性内脏传入

• 批准号: 2409667
• 负责人: JYOTI N SENGUPTA
• 金额: $ 17.18万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2409667
• 关键词: chemical stimulation; gastrointestinal disorder; gastrointestinal motility /pressure; gastrointestinal system; inflammation; intestinal mucosa; intestine disorder; laboratory rat; mucosa; muscle; pain; sensory mechanism; small intestines; splanchnic nerves; stomach disorder; temperature; vagus nerve; visceral afferent nerve

Pain arising from the viscera is associated with a variety of disorders. The major goal of this research proposal is to improve our understanding of the peripheral mechanisms of visceral pain under normal physiological and pathophysiological conditions. Single fiber studies will be undertaken to understand the role of primary visceral afferents in gastrointestinal (GI) pain. The aims involve characterization of responses of muscle and mucosal afferents in the vagus and splanchnic nerves of the rat to mechanical, thermal and chemical stimuli under normal physiological and inflammatory conditions. Experiments will address the following aims: 1) Quantitative characterization of vagal and splanchnic nerve afferents in these two pathways to graded distension will be compared to understand their relative roles in regulatory functions and nociception. The locations of mechanosensitive receptive fields in the stomach and small intestine will be determined. 2) Determine response-specificity of vagal and splanchnic nerve afferents and determine whether mechanically-insensitive afferents innervating the upper GI tract are truly silent or are chemo- and/or thermo-sensitive. 3) Quantitatively characterize the mechano, thermo- and chemo- sensitive properties of vagal and splanchnic nerve afferents innervating the chronically inflamed stomach and small intestine. 4) Quantitatively characterize the mechano, thermo- and chemo- sensitive properties of vagal and splanchnic nerve afferents innervating the chronically inflamed stomach and small intestine. This proposal represents the first systematic investigation of the possible roles of primary afferents in upper GI pain. The study will provide information about the adequate natural stimuli of the afferents ad about changes in response characteristics during inflammation.

内脏引起的疼痛与多种疾病有关。 本研究计划的主要目标是改善我们的 了解内脏疼痛的外周机制 正常的生理和病理生理条件。 单纤 将进行研究以了解初级内脏的作用 胃肠道（GI）疼痛的传入。 目标包括 肌肉和粘膜传入反应的表征 大鼠迷走神经和内脏神经对机械、热和 正常生理和炎症下的化学刺激 状况。 实验将实现以下目标：1） 迷走神经和内脏神经传入的定量特征 这两种分级扩张途径将被比较 了解它们在调节功能和伤害感受中的相对作用。 胃中机械敏感感受野的位置 小肠将被确定。 2) 确定迷走神经和内脏神经的反应特异性 传入并确定是否是机械不敏感的传入 神经支配上胃肠道确实是沉默的或者是化疗和/或 热敏的。 3) 定量表征机械、热和化学特性 迷走神经和内脏神经传入神经的敏感特性 胃和小肠慢性发炎。 4) 定量表征机械、热和化学特性 迷走神经和内脏神经传入神经的敏感特性 胃和小肠慢性发炎。 该提案代表了对这一问题的首次系统调查。 初级传入神经在上消化道疼痛中的可能作用。 该研究将 提供有关传入神经的充分自然刺激的信息 关于炎症期间反应特征变化的广告。