PRIMARY VISCERAL AFFERENTS IN PAIN

疼痛时的原发性内脏传入

• 批准号: 2685753
• 负责人: JYOTI N SENGUPTA
• 金额: $ 13.51万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685753
• 关键词: chemical stimulation; gastrointestinal disorder; gastrointestinal motility /pressure; gastrointestinal system; inflammation; intestinal mucosa; intestine disorder; laboratory rat; mucosa; muscle; pain; sensory mechanism; small intestines; splanchnic nerves; stomach disorder; temperature; vagus nerve; visceral afferent nerve

Pain arising from the viscera is associated with a variety of disorders. The major goal of this research proposal is to improve our understanding of the peripheral mechanisms of visceral pain under normal physiological and pathophysiological conditions. Single fiber studies will be undertaken to understand the role of primary visceral afferents in gastrointestinal (GI) pain. The aims involve characterization of responses of muscle and mucosal afferents in the vagus and splanchnic nerves of the rat to mechanical, thermal and chemical stimuli under normal physiological and inflammatory conditions. Experiments will address the following aims: 1) Quantitative characterization of vagal and splanchnic nerve afferents in these two pathways to graded distension will be compared to understand their relative roles in regulatory functions and nociception. The locations of mechanosensitive receptive fields in the stomach and small intestine will be determined. 2) Determine response-specificity of vagal and splanchnic nerve afferents and determine whether mechanically-insensitive afferents innervating the upper GI tract are truly silent or are chemo- and/or thermo-sensitive. 3) Quantitatively characterize the mechano, thermo- and chemo- sensitive properties of vagal and splanchnic nerve afferents innervating the chronically inflamed stomach and small intestine. 4) Quantitatively characterize the mechano, thermo- and chemo- sensitive properties of vagal and splanchnic nerve afferents innervating the chronically inflamed stomach and small intestine. This proposal represents the first systematic investigation of the possible roles of primary afferents in upper GI pain. The study will provide information about the adequate natural stimuli of the afferents ad about changes in response characteristics during inflammation.

内脏引起的疼痛与多种疾病有关。 这项研究建议的主要目标是改善我们的 了解内脏疼痛的外围机制 正常的生理和病理生理状况。 单纤维 将进行研究以了解主要内脏的作用 胃肠道（GI）疼痛的传入。 目的涉及 表征肌肉和粘膜传入的反应 大鼠的迷走神经和闪烁的神经对机械，热和 在正常生理和炎症下化学刺激 状况。 实验将解决以下目标：1） 迷走神经和神经神经传感的定量表征 将这两种分级扩张的途径与 了解它们在调节功能和伤害感受中的相对作用。 胃中的机械敏感接收场的位置 小肠将被确定。 2）确定迷走神经和神经神经的响应特异性 传入并确定机械不敏感的传入 支配上层胃肠道是真正的静音或化学和/或 热敏感。 3）定量表征机械，热和化学 神经支配的迷走神经和神经传入的敏感特性 长期发炎的胃和小肠。 4）定量表征机械，热和化学 神经支配的迷走神经和神经传入的敏感特性 长期发炎的胃和小肠。 该提案代表了对 主要传入中胃肠痛的可能作用。 研究将 提供有关传入的足够自然刺激的信息 关于炎症过程中响应特征的变化的广告。