REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY

重复行为模式——发展

• 批准号: 2034945
• 负责人: MARK H LEWIS
• 金额: $ 15.52万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2034945
• 关键词: Peromyscus; RNase protection assay; animal developmental psychology; animal ecology; autoradiography; behavioral /social science research tag; dopamine receptor; endogenous opioid; ethology; high performance liquid chromatography; image processing; in situ hybridization; instinct; neurobiology; operant conditionings; radioimmunoassay; receptor binding; receptor expression; statistics /biometry

DESCRIPTION:(Adapted from applicant's abstract): Stereotypy refers to behavior that is repetitive, rhythmical, topographically invariant, and without an obvious function. Although stereotypies can be observed in many species in different contexts, such behavior is typically associated, in humans, with various psychiatric, neurological, and developmental disorders, and, in animals, with adverse environmental circumstances. Although studies using pharmacological models of stereotyped behavior have identified important brain mechanisms, little is known about the neurobiological basis or function of spontaneous stereotypes in animals or humans. The investigators propose to study the development and neurobiological basis of abnormal stereotyped behavior in wild-type muroid rodents. A laboratory based rodent model offers significant advantages for these kinds of studies as much is known about the neurobiology of these species and large numbers of animals can be rapidly bred. The proposed studies will have three aims: To characterize the development of stereotyped behavior in deer mice; to prevent the development of abnormal stereotyped behavior by early environmental enrichment; and to identify important neurobiological mechanisms that mediate the development and expression of stereotyped behavior. Successful completion of the proposed studies will provide important information about the pathophysiology and treatment of stereotypic movement disorder in humans. Moreover, these studies will address basic brain mechanisms that mediate environmentally-induced stereotyped behavior, and the function of such behavior for the biological organism.

描述：（改编自申请人的摘要）：刻板印象是指 重复性，有节奏，地形上不变的行为，并且 没有明显的功能。 尽管在许多人中可以观察到刻板印象 在不同情况下的物种，这种行为通常与 人类患有各种精神病，神经和发育障碍， 在动物中，环境不利。 虽然研究 使用刻板印象的药理模型已确定 重要的大脑机制，对神经生物学基础知之甚少 或动物或人类自发刻板印象的功能。 这 研究人员建议研究的发展和神经生物学基础 野生型鼠啮齿动物的异常定型行为。 实验室 基于啮齿动物的模型为这类研究提供了重要的优势 对这些物种的神经生物学和大量的神经生物学知之甚少 动物可以迅速繁殖。 拟议的研究将有三个目标： 表征鹿小鼠刻板印象行为的发展；到 防止早期发展异常定型行为 环境丰富；并确定重要的神经生物学 介导刻板印象的发展和表达的机制 行为。 拟议研究的成功完成将提供 有关刻板印象的病理生理学和治疗的重要信息 人类运动障碍。 而且，这些研究将解决基本 介导环境引起的定型行为的大脑机制， 以及这种行为在生物生物体中的功能。