MAMMALIAN BRAIN MAST CELLS AND REPRODUCTION

哺乳动物脑肥大细胞和繁殖

• 批准号: 2332648
• 负责人: Colleen M Novak
• 金额: $ 1.45万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-10 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2332648
• 关键词: MAMMALIAN; BRAIN; MAST; CELLS; REPRODUCTION

the research described here is intended to investigate the involvement of brain mast cells in the reproductive functions of male Syrian hamsters. The hamster is an attractive model to investigate the role of gonadotropin releasing hormone immunopositive (GnRH+) mast cells because the number of these cells in the brain is affected by the reproductive status of the animal (i.e., more cells are seen in photostimulated, reproductively active males). A similar correlation between cell number and reproductive competence has also been seen in doves and may be a common feature in vertebrates. The aims of this study are to (1) Confirm the phenotype of the GnRH+ non-neuronal cells as mast cells using electron microscopy, (2) Determine if GnRH+ mast cell induction in the brain is steroid-independent, and (3) Determine the relevant socio-sexual conditions under which GnRH+ mast cells migrate into the brain.

此处描述的研究旨在调查参与 男性叙利亚人的生殖功能中的脑肥大细胞的 仓鼠。 仓鼠是一个有吸引力的模型，用于研究 促性腺激素释放激素免疫阳性（GNRH+）肥大细胞，因为 大脑中这些细胞的数量受生殖的影响 动物的状态（即，在光刺激中看到更多的细胞， 生殖活跃的雄性）。 单元格之间的类似相关性 在鸽子中也可以看到生殖能力 脊椎动物中的共同特征。 这项研究的目的是（1）确认 GNRH+非神经元细胞作为肥大细胞的表型使用 电子显微镜，（2）确定GNRH+肥大细胞是否在 大脑独立于类固醇，（3）确定相关的社会性别 GNRH+肥大细胞迁移到大脑的条件。

项目成果

Daily rhythms in Fos activity in the rat ventrolateral preoptic area and midline thalamic nuclei.

• DOI: 10.1152/ajpregu.1998.275.5.r1620
• 发表时间: 1998-11
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: C. Novak;A. Núñez