DEVELOPMENT AND REGULATION OF EMOTION

情绪的发展和调节

• 批准号: 2445496
• 负责人: Ned H Kalin
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2445496
• 关键词: Macaca mulatta; aggression; amygdala; autogenic training; avoidance behavior; behavior test; behavioral /social science research tag; cerebral dominance; ethology; experimental brain lesion; fear; heart rate; ibotenate; neural information processing; neuroanatomy; psychobiology; psychological stressor; small social group; social behavior; social dominance; social group process; telemetry; videotape /videodisc

The overall objective of the proposed research is to understand the neural systems underlying the expression of emotion in primates. We have focused on elucidating mechanisms underlying the expression of fear and anxiety. This is an area of great importance because when appropriate, fear- motivation behaviors are adaptive; however, when overly intense of expressed out of context, extreme fear is characteristics of many forms of psychopathology. Studies will focus on the role of the amygdala in mediating fearful states. Although many studies have been performed in rodents, studies in nonhuman primates are important because they provide a basis for understanding the role of the amygdala in humans. Important differences in social behavior and cortical amygdala linkages between rodents and primates highlight the necessity of performing research to close the psychopathology are found in nonhuman primates. We will use state-of-the-art techniques to lesion the amygdala and its nuclei. Most prior studies in primates have used lesioning techniques that have not been selective, resulting in damage to other sub-cortical and cortical regions. In addition to complete amygdala lesions, lesions of the central and lateral nuclei will be made. These sites are of interest because they are the major points at which information enters and leaves the amygdala. The effects of these lesions on the following parameters will be assessed: 1) classically conditioned autonomic responses, 2) ethologically relevant threatening stimuli, and 3) affiliative and defensive behavior expressed in social situations. Eventually, these studies will define biological mechanisms regulating the expression of the primate's adaptive responding to threatening stimuli. These findings will provide insight into mechanisms mediating maladaptive responding in humans, which is characteristic of fear-related psychopathology.

拟议研究的总体目标是了解神经 灵长类动物中情绪表达的基础。 我们专注于 阐明恐惧和焦虑表达的基础机制。 这是一个非常重要的领域，因为在适当的情况下，恐惧 - 动机行为是适应性的；但是，当过度强烈 出于上下文而表达，极端恐惧是多种形式的特征 心理病理学。 研究将侧重于杏仁核在介导可怕国家中的作用。 尽管在啮齿动物中进行了许多研究，但在非人类中进行了研究 灵长类动物很重要，因为它们为理解 杏仁核在人类中的作用。 社会行为的重要差异 啮齿动物和灵长类动物之间的皮质杏仁核连接突出了 进行研究以关闭心理病理学的必要性在 非人类灵长类动物。 我们将使用最先进的技术来病变 杏仁核及其核。 大多数先前在灵长类动物中的研究已经使用 尚未选择性的病变技术，导致损害 其他亚皮质和皮质区域。 除了完成杏仁核 将产生病变，中央和侧核的病变。 这些 网站很感兴趣，因为它们是主要点 信息进入并离开杏仁核。 这些病变的影响 将评估以下参数：1）经典条件 自主反应，2）与伦理学相关的威胁性刺激和3） 在社交情况下表达的从属和防御行为。 最终，这些研究将定义调节的生物学机制 灵长类动物适应性的表达对威胁刺激的反应。 这些发现将提供有关介导不良适应性机制的洞察力 在人类中回应，这是与恐惧有关的特征 心理病理学。