MEDICAL INTERVENTION EFFECTIVENESS AND OUTCOMES IN COPD

慢性阻塞性肺病的医疗干预效果和结果

• 批准号: 2031786
• 负责人: DAVID R CARTER
• 金额: $ 24.19万
• 依托单位: UNIVERSITY OF TEXAS HLTH CTR AT TYLER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2031786
• 关键词: aerobic exercise; behavioral /social science research tag; blood chemistry; chronic obstructive pulmonary disease; clinical research; clinical trials; dyspneas; functional ability; health services research tag; human subject; human therapy evaluation; lactates; longitudinal human study; muscle metabolism; outcomes research; patient care management; quality of life; respiratory gas level; training level

DESCRIPTION: The study seeks to determine if exercise training above the measured lactic threshold improves performance more than training below the lactic threshold in patients with chronic obstructive pulmonary disease (COPD); to determine if delayed release of lactic acids of blood results in a reduction of dyspnea; and to determine if changes in lactic acid in dyspnea translate into improved quality of life. The working hypotheses are that exercise training will reduce dyspnea by circulating lactic acid; high intensity training will improve function more and reduce lactic acid to a greater extent than low intensity training; and the benefits of exercise training will improve measured quality of life. Recent data indicate that education in other cognitive interventions failed to alter functional capacity in dyspnea patients with COPD. Rehabilitation, specifically exercise intervention, has resulted in performance gains for patients. The results of rehabilitation training, however, are variable, suggesting that exercise training has not yet been optimized. Patients will be randomly assigned to one of two experimental groups; high intensity versus low intensity exercise training. Randomization will also be blocked by smoking status. Prior to the intervention, measurement of respiratory gas exchange, acid, dyspnea, and quality of life will be used to stratify the patients. Patients will complete 16 weeks of supervised exercise training followed by a long-term maintenance program for total follow-up of one year. The primary endpoints are changes in the lactic threshold and dyspnea, with the assumption that these should translate into improved quality of life.

描述：研究旨在确定上述运动训练是否 测得的乳酸阈值比训练更多地提高了性能 慢性阻塞性患者的乳酸阈值以下 肺部疾病（COPD）；确定乳酸的延迟释放是否 血液的酸会导致呼吸困难降低；并确定是否 呼吸困难的乳酸的变化转化为提高的质量 生活。工作假设是运动训练将减少 通过循环乳酸呼吸困难；高强度训练将改善 比低的功能更大，并减少乳酸的程度更大 强度训练；运动训练的好处将有所改善 测量的生活质量。 最近的数据表明，其他认知干预措施的教育 无法改变COPD呼吸困难患者的功能能力。 康复，特别是运动干预，导致了 患者的表现增长。康复培训的结果， 但是，有变量，表明运动训练尚未 被优化。患者将被随机分配给两个 实验组；高强度与低强度运动 训练。随机化也将因吸烟状况而阻止。 干预之前，测量呼吸道气交换， 酸，呼吸困难和生活质量将用于分层 患者。患者将完成16周的监督运动 培训，然后进行长期维护计划，以进行全面随访 一年。主要终点是乳酸阈值的变化 和呼吸困难，假设这些应该转化为 改善生活质量。