TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
基本信息
- 批准号:6389409
- 负责人:
- 金额:$ 41.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-06-15 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:aerobic exercise behavioral /social science research tag blood chemistry body physical activity cardiovascular stress test clinical research clinical trials disease /disorder prevention /control drug administration rate /duration essential hypertension exercise gender difference human middle age (35-64) human subject human therapy evaluation longitudinal human study outcomes research patient care management psychological adaptation psychological tests questionnaires racial /ethnic difference therapy compliance
项目摘要
DESCRIPTION: (Adapted from Investigator's Abstract) Arterial hypertension
affects over 50 million Americans. While drug treatment is effective,
exercise would be safer, might be cheaper, and would bring added health
benefits if it could replace drugs in controlling hypertension. The aims of
this study are to: 1) determine if two 18 month long endurance training
programs, one of high intensity and one of moderate intensity, can replace
medication as a treatment for mild essential hypertension, 2) determine if a
moderate intensity endurance training program is as effective as or more
effective than a high intensity program in allowing mild essential
hypertensives to discontinue anti-hypertensive medication, 3) determine if
physiological, psychological, and compliance variables predict success in
allowing mild essential hypertensives to discontinue anti-hypertensive
medication. The investigators propose a randomized controlled trial. Known
hypertensives (n=162) whose diastolic blood pressures rises to between 90
and 104 within four months of discontinuing medication under careful
observation will have their pressures controlled with enalapril. Half the
subjects will be female and half male, and their racial characteristics will
generally reflect that of our managed care population (about 20% black).
V02 peak will be measured during cycle ergometry. Eligible subjects will be
randomly assigned to 18 months participation in one of three groups: 1)
high intensity endurance training (35 minutes 3 times/week at heart rate at
70-85% of V02 peak), 2) moderate intensity endurance training (35 minutes 3
times/week at heart rate of 50-70 of V02 peak), and 3) contact control.
Enalapril will be forward or back titrated or discontinued to maintain a
normal blood pressure. After 12 months participation, medication will be
withdrawn under careful supervision from all subjects still taking it. They
will test the hypotheses that: 1) a greater number of subjects undergoing
either or both of the two 18 month exercise training programs will be able
to stop anti-hypertensive medication than non-exercising controls, 2)
moderate and high intensity endurance training are equally effective in
replacing drugs in the treatment of mild essential hypertension, and 3)
subjects that are successful at withdrawing anti-hypertensive medication
will have: greater improvements in V02 peak, better initial psychological
status or greater improvements in psychological status, and greater
compliance with the exercise training program. The investigators state that
this study will be a critical test of whether endurance training can replace
medication in an important number of patients as a treatment for
hypertension.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOEL D POSNER其他文献
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{{ truncateString('JOEL D POSNER', 18)}}的其他基金
More effective exercise modalities in older CHF patients
老年慢性心力衰竭患者更有效的运动方式
- 批准号:
7155403 - 财政年份:2004
- 资助金额:
$ 41.99万 - 项目类别:
More effective exercise modalities in older CHF patients
老年慢性心力衰竭患者更有效的运动方式
- 批准号:
7114977 - 财政年份:2004
- 资助金额:
$ 41.99万 - 项目类别:
More effective exercise modalities in older CHF patients
老年慢性心力衰竭患者更有效的运动方式
- 批准号:
6820039 - 财政年份:2004
- 资助金额:
$ 41.99万 - 项目类别:
TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
- 批准号:
6183770 - 财政年份:1997
- 资助金额:
$ 41.99万 - 项目类别:
TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
- 批准号:
2714122 - 财政年份:1997
- 资助金额:
$ 41.99万 - 项目类别:
TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
- 批准号:
6017295 - 财政年份:1997
- 资助金额:
$ 41.99万 - 项目类别:
TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
- 批准号:
2030264 - 财政年份:1997
- 资助金额:
$ 41.99万 - 项目类别:
EFFECTS OF HYPOTHALAMIC/PITUITARY/ADRENAL AXIS ON DOPAMINE ACTIVITY
下丘脑/垂体/肾上腺轴对多巴胺活性的影响
- 批准号:
6252467 - 财政年份:1997
- 资助金额:
$ 41.99万 - 项目类别:
TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES
用两种运动强度治疗高血压
- 批准号:
6032291 - 财政年份:1997
- 资助金额:
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用两种运动强度治疗高血压
- 批准号:
6183770 - 财政年份:1997
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