TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES

用两种运动强度治疗高血压

• 批准号: 6389409
• 负责人: JOEL D POSNER
• 金额: $ 41.99万
• 依托单位: MCP HAHNEMANN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6389409
• 关键词: aerobic exercise; behavioral /social science research tag; blood chemistry; body physical activity; cardiovascular stress test; clinical research; clinical trials; disease /disorder prevention /control; drug administration rate /duration; essential hypertension; exercise; gender difference; human middle age (35-64); human subject; human therapy evaluation; longitudinal human study; outcomes research; patient care management; psychological adaptation; psychological tests; questionnaires; racial /ethnic difference; therapy compliance

DESCRIPTION: (Adapted from Investigator's Abstract) Arterial hypertension affects over 50 million Americans. While drug treatment is effective, exercise would be safer, might be cheaper, and would bring added health benefits if it could replace drugs in controlling hypertension. The aims of this study are to: 1) determine if two 18 month long endurance training programs, one of high intensity and one of moderate intensity, can replace medication as a treatment for mild essential hypertension, 2) determine if a moderate intensity endurance training program is as effective as or more effective than a high intensity program in allowing mild essential hypertensives to discontinue anti-hypertensive medication, 3) determine if physiological, psychological, and compliance variables predict success in allowing mild essential hypertensives to discontinue anti-hypertensive medication. The investigators propose a randomized controlled trial. Known hypertensives (n=162) whose diastolic blood pressures rises to between 90 and 104 within four months of discontinuing medication under careful observation will have their pressures controlled with enalapril. Half the subjects will be female and half male, and their racial characteristics will generally reflect that of our managed care population (about 20% black). V02 peak will be measured during cycle ergometry. Eligible subjects will be randomly assigned to 18 months participation in one of three groups: 1) high intensity endurance training (35 minutes 3 times/week at heart rate at 70-85% of V02 peak), 2) moderate intensity endurance training (35 minutes 3 times/week at heart rate of 50-70 of V02 peak), and 3) contact control. Enalapril will be forward or back titrated or discontinued to maintain a normal blood pressure. After 12 months participation, medication will be withdrawn under careful supervision from all subjects still taking it. They will test the hypotheses that: 1) a greater number of subjects undergoing either or both of the two 18 month exercise training programs will be able to stop anti-hypertensive medication than non-exercising controls, 2) moderate and high intensity endurance training are equally effective in replacing drugs in the treatment of mild essential hypertension, and 3) subjects that are successful at withdrawing anti-hypertensive medication will have: greater improvements in V02 peak, better initial psychological status or greater improvements in psychological status, and greater compliance with the exercise training program. The investigators state that this study will be a critical test of whether endurance training can replace medication in an important number of patients as a treatment for hypertension.

描述：（根据研究者的摘要改编）动脉高血压 影响超过5000万美国人。 虽然药物治疗有效，但 锻炼会更安全，可能会更便宜，并且会带来更多的健康 好处，如果它可以替代控制高血压的药物。 目的 这项研究是：1）确定是否两个18个月长的耐力训练 节目是高强度之一，并且强度之一可以代替 药物作为轻度基本高血压的治疗方法，2）确定是否a 中等强度的耐力训练计划与或更多 比高强度计划有效，可以轻度必要 高血压以中断抗高血压药物，3）确定是否是否 生理，心理和合规变量预测 允许轻度基本高血压停止抗高血压 药物。 研究人员提出了一项随机对照试验。 已知 高血压（n = 162），其舒张血压升至90之间 和104在仔细暂停药物后四个月内 观察将使他们的压力控制着依那倍莱。 一半 受试者将是女性和一半男性，其种族特征将 通常反映我们的托管护理人群（约20％黑色）。 V02峰将在循环测量值期间测量。 合格的主题将是 随机分配为18个月的三组之一：1） 高强度耐力训练（35分钟3次/周以心率为单位 V02峰的70-85％），2）中等强度耐力训练（35分钟3 每周的心率为50-70的V02峰值）和3）接触对照。 依那普利将被滴定或退中心或终止 正常血压。 参与12个月后，药物将是 在所有受试者的仔细监督下撤回仍在接受。 他们 将检验以下假设：1）更多受试者正在接受 两个18个月的锻炼训练计划中的任何一个或两个都将能够 与非行动控制相比，停止抗高血压药物，2） 中度和高强度耐力训练同样有效 在治疗轻度高血压治疗时取代药物，3） 成功撤回抗高血压药物的受试者 将有：V02峰的进步，更好的初始心理 地位或心理状况的改善和更大的改善 遵守运动训练计划。 调查人员指出 这项研究将是对耐力训练是否可以替代的关键测试 重要的患者中的药物作为治疗 高血压。